Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers
Background Sedentary behavior is pervasive, especially in older adults, and is associated with cardiometabolic disease and mortality. Relationships between cardiometabolic biomarkers and sitting time are unexplored in older women, as are possible ethnic differences. Methods and Results Ethnic differ...
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013403 |
| _version_ | 1797884434254397440 |
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| author | Ya‐Ju Chang John Bellettiere Suneeta Godbole Samaneh Keshavarz Joseph P. Maestas Jonathan T. Unkart Daniel Ervin Matthew A. Allison Cheryl L. Rock Ruth E. Patterson Marta M. Jankowska Jacqueline Kerr Loki Natarajan Dorothy D. Sears |
| author_facet | Ya‐Ju Chang John Bellettiere Suneeta Godbole Samaneh Keshavarz Joseph P. Maestas Jonathan T. Unkart Daniel Ervin Matthew A. Allison Cheryl L. Rock Ruth E. Patterson Marta M. Jankowska Jacqueline Kerr Loki Natarajan Dorothy D. Sears |
| author_sort | Ya‐Ju Chang |
| collection | DOAJ |
| description | Background Sedentary behavior is pervasive, especially in older adults, and is associated with cardiometabolic disease and mortality. Relationships between cardiometabolic biomarkers and sitting time are unexplored in older women, as are possible ethnic differences. Methods and Results Ethnic differences in sitting behavior and associations with cardiometabolic risk were explored in overweight/obese postmenopausal women (n=518; mean±SD age 63±6 years; mean body mass index 31.4±4.8 kg/m2). Accelerometer data were processed using validated machine‐learned algorithms to measure total daily sitting time and mean sitting bout duration (an indicator of sitting behavior pattern). Multivariable linear regression was used to compare sitting among Hispanic women (n=102) and non‐Hispanic women (n=416) and tested associations with cardiometabolic risk biomarkers. Hispanic women sat, on average, 50.3 minutes less/day than non‐Hispanic women (P<0.001) and had shorter (3.6 minutes less, P=0.02) mean sitting bout duration. Among all women, longer total sitting time was deleteriously associated with fasting insulin and triglyceride concentrations, insulin resistance, body mass index and waist circumference; longer mean sitting bout duration was deleteriously associated with fasting glucose and insulin concentrations, insulin resistance, body mass index and waist circumference. Exploratory interaction analysis showed that the association between mean sitting bout duration and fasting glucose concentration was significantly stronger among Hispanic women than non‐Hispanic women (P‐interaction=0.03). Conclusions Ethnic differences in 2 objectively measured parameters of sitting behavior, as well as detrimental associations between parameters and cardiometabolic biomarkers were observed in overweight/obese older women. The detrimental association between mean sitting bout duration and fasting glucose may be greater in Hispanic women than in non‐Hispanic women. Corroboration in larger studies is warranted. |
| first_indexed | 2024-04-10T04:06:11Z |
| format | Article |
| id | doaj.art-be9461a70f2540beb9effe0faffad34e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T04:06:11Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-be9461a70f2540beb9effe0faffad34e2023-03-13T05:25:33ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-02-019410.1161/JAHA.119.013403Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk BiomarkersYa‐Ju Chang0John Bellettiere1Suneeta Godbole2Samaneh Keshavarz3Joseph P. Maestas4Jonathan T. Unkart5Daniel Ervin6Matthew A. Allison7Cheryl L. Rock8Ruth E. Patterson9Marta M. Jankowska10Jacqueline Kerr11Loki Natarajan12Dorothy D. Sears13Department of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CASchool of Medicine and Health Sciences The George Washington University Washington DCDepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Research The East‐West Center Honolulu HIDepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CACalit2/Qualcomm Institute UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CADepartment of Family Medicine and Public Health UC San Diego La Jolla CABackground Sedentary behavior is pervasive, especially in older adults, and is associated with cardiometabolic disease and mortality. Relationships between cardiometabolic biomarkers and sitting time are unexplored in older women, as are possible ethnic differences. Methods and Results Ethnic differences in sitting behavior and associations with cardiometabolic risk were explored in overweight/obese postmenopausal women (n=518; mean±SD age 63±6 years; mean body mass index 31.4±4.8 kg/m2). Accelerometer data were processed using validated machine‐learned algorithms to measure total daily sitting time and mean sitting bout duration (an indicator of sitting behavior pattern). Multivariable linear regression was used to compare sitting among Hispanic women (n=102) and non‐Hispanic women (n=416) and tested associations with cardiometabolic risk biomarkers. Hispanic women sat, on average, 50.3 minutes less/day than non‐Hispanic women (P<0.001) and had shorter (3.6 minutes less, P=0.02) mean sitting bout duration. Among all women, longer total sitting time was deleteriously associated with fasting insulin and triglyceride concentrations, insulin resistance, body mass index and waist circumference; longer mean sitting bout duration was deleteriously associated with fasting glucose and insulin concentrations, insulin resistance, body mass index and waist circumference. Exploratory interaction analysis showed that the association between mean sitting bout duration and fasting glucose concentration was significantly stronger among Hispanic women than non‐Hispanic women (P‐interaction=0.03). Conclusions Ethnic differences in 2 objectively measured parameters of sitting behavior, as well as detrimental associations between parameters and cardiometabolic biomarkers were observed in overweight/obese older women. The detrimental association between mean sitting bout duration and fasting glucose may be greater in Hispanic women than in non‐Hispanic women. Corroboration in larger studies is warranted.https://www.ahajournals.org/doi/10.1161/JAHA.119.013403ActiGraphcardiovascular riskglucoregulatoryLatinamachine learningtype 2 diabetes |
| spellingShingle | Ya‐Ju Chang John Bellettiere Suneeta Godbole Samaneh Keshavarz Joseph P. Maestas Jonathan T. Unkart Daniel Ervin Matthew A. Allison Cheryl L. Rock Ruth E. Patterson Marta M. Jankowska Jacqueline Kerr Loki Natarajan Dorothy D. Sears Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ActiGraph cardiovascular risk glucoregulatory Latina machine learning type 2 diabetes |
| title | Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers |
| title_full | Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers |
| title_fullStr | Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers |
| title_full_unstemmed | Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers |
| title_short | Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers |
| title_sort | total sitting time and sitting pattern in postmenopausal women differ by hispanic ethnicity and are associated with cardiometabolic risk biomarkers |
| topic | ActiGraph cardiovascular risk glucoregulatory Latina machine learning type 2 diabetes |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013403 |
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