Early predictors of visual and axonal outcomes after acute optic neuritis
BackgroundPredicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lacking.ObjectivesUsing a prospective study method, to...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.945034/full |
| _version_ | 1798036933327192064 |
|---|---|
| author | Minh N. L. Nguyen Minh N. L. Nguyen Chao Zhu Scott C. Kolbe Helmut Butzkueven Helmut Butzkueven Owen B. White Owen B. White Joanne Fielding Trevor J. Kilpatrick Gary F. Egan Alexander Klistorner Anneke van der Walt Anneke van der Walt |
| author_facet | Minh N. L. Nguyen Minh N. L. Nguyen Chao Zhu Scott C. Kolbe Helmut Butzkueven Helmut Butzkueven Owen B. White Owen B. White Joanne Fielding Trevor J. Kilpatrick Gary F. Egan Alexander Klistorner Anneke van der Walt Anneke van der Walt |
| author_sort | Minh N. L. Nguyen |
| collection | DOAJ |
| description | BackgroundPredicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lacking.ObjectivesUsing a prospective study method, to identify 1 and 3 months predictors of 6 and 12 months visual outcome (low contrast letter acuity 2.5%) and axonal loss [retinal nerve fiber layer thickness and multifocal evoked potential (mfVEP) amplitude] following acute ON.MethodsIn total, 37 patients of acute ON onset were evaluated within 14 days using between-eye asymmetry of visual acuity, color vision (Ishihara plates), optical coherence tomography, mfVEP, and optic nerve magnetic resonance imaging [magnetic transfer ratio (MTR) and diffusion tensor imaging (DTI)].ResultsVisual outcome at 6 and 12 months was best predicted by Ishihara asymmetry at 1 and 3 months following ON onset. Axonal loss at 6 and 12 months was reliably predicted by Ishihara asymmetry at 1 month. Optic nerve MTR and DTI at 3 months post-acute ON could predict axonal loss at 6 and 12 months.ConclusionsSimple Ishihara asymmetry testing 1 month after acute ON onset can best predict visual outcome and axonal loss at 6 and 12 months in a clinical or research setting. |
| first_indexed | 2024-04-11T21:19:45Z |
| format | Article |
| id | doaj.art-be94646d4bf141bf9437d8c3efe16a30 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T21:19:45Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-be94646d4bf141bf9437d8c3efe16a302022-12-22T04:02:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.945034945034Early predictors of visual and axonal outcomes after acute optic neuritisMinh N. L. Nguyen0Minh N. L. Nguyen1Chao Zhu2Scott C. Kolbe3Helmut Butzkueven4Helmut Butzkueven5Owen B. White6Owen B. White7Joanne Fielding8Trevor J. Kilpatrick9Gary F. Egan10Alexander Klistorner11Anneke van der Walt12Anneke van der Walt13Department of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurology, Alfred Health, Melbourne, VIC, AustraliaDepartment of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurology, Alfred Health, Melbourne, VIC, AustraliaDepartment of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurology, Alfred Health, Melbourne, VIC, AustraliaDepartment of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurology, Royal Melbourne Hospital, Melbourne, VIC, AustraliaMonash Biomedical Imaging, Monash University, Melbourne, VIC, AustraliaSave Sight Institute, University of Sydney, Sydney, NSW, AustraliaDepartment of Neurosciences, Monash University, Melbourne, VIC, AustraliaDepartment of Neurology, Alfred Health, Melbourne, VIC, AustraliaBackgroundPredicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lacking.ObjectivesUsing a prospective study method, to identify 1 and 3 months predictors of 6 and 12 months visual outcome (low contrast letter acuity 2.5%) and axonal loss [retinal nerve fiber layer thickness and multifocal evoked potential (mfVEP) amplitude] following acute ON.MethodsIn total, 37 patients of acute ON onset were evaluated within 14 days using between-eye asymmetry of visual acuity, color vision (Ishihara plates), optical coherence tomography, mfVEP, and optic nerve magnetic resonance imaging [magnetic transfer ratio (MTR) and diffusion tensor imaging (DTI)].ResultsVisual outcome at 6 and 12 months was best predicted by Ishihara asymmetry at 1 and 3 months following ON onset. Axonal loss at 6 and 12 months was reliably predicted by Ishihara asymmetry at 1 month. Optic nerve MTR and DTI at 3 months post-acute ON could predict axonal loss at 6 and 12 months.ConclusionsSimple Ishihara asymmetry testing 1 month after acute ON onset can best predict visual outcome and axonal loss at 6 and 12 months in a clinical or research setting.https://www.frontiersin.org/articles/10.3389/fneur.2022.945034/fulloptic neuritisprognosisOCTMRIIshihara |
| spellingShingle | Minh N. L. Nguyen Minh N. L. Nguyen Chao Zhu Scott C. Kolbe Helmut Butzkueven Helmut Butzkueven Owen B. White Owen B. White Joanne Fielding Trevor J. Kilpatrick Gary F. Egan Alexander Klistorner Anneke van der Walt Anneke van der Walt Early predictors of visual and axonal outcomes after acute optic neuritis Frontiers in Neurology optic neuritis prognosis OCT MRI Ishihara |
| title | Early predictors of visual and axonal outcomes after acute optic neuritis |
| title_full | Early predictors of visual and axonal outcomes after acute optic neuritis |
| title_fullStr | Early predictors of visual and axonal outcomes after acute optic neuritis |
| title_full_unstemmed | Early predictors of visual and axonal outcomes after acute optic neuritis |
| title_short | Early predictors of visual and axonal outcomes after acute optic neuritis |
| title_sort | early predictors of visual and axonal outcomes after acute optic neuritis |
| topic | optic neuritis prognosis OCT MRI Ishihara |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.945034/full |
| work_keys_str_mv | AT minhnlnguyen earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT minhnlnguyen earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT chaozhu earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT scottckolbe earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT helmutbutzkueven earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT helmutbutzkueven earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT owenbwhite earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT owenbwhite earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT joannefielding earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT trevorjkilpatrick earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT garyfegan earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT alexanderklistorner earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT annekevanderwalt earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis AT annekevanderwalt earlypredictorsofvisualandaxonaloutcomesafteracuteopticneuritis |