Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis
Abstract Background The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. Methods Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case–control...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
|
| Series: | Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13054-022-04032-x |
| _version_ | 1818207759421669376 |
|---|---|
| author | Guobin Wang Chunyan Jiang Junjun Fang Zhitao Li Hongliu Cai |
| author_facet | Guobin Wang Chunyan Jiang Junjun Fang Zhitao Li Hongliu Cai |
| author_sort | Guobin Wang |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. Methods Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case–control studies were extracted for the meta-analysis. Multivariate regression analysis was used to evaluate the correlation of the outcomes with sample size and male proportion. Results A total of 17 studies covering 3658 sepsis patients were included. PTX3 level was significantly higher in non-survivor compared to survivor patients (SMD (95% CI): −1.06 (−1.43, −0.69), P < 0.001). Increased PTX3 level was significantly associated with mortality (HR (95% CI): 2.09 (1.55, 2.81), P < 0.001). PTX3 showed good predictive capability for mortality (AUC:ES (95% CI): 0.73 (0.70, 0.77), P < 0.001). The outcome comparing PTX3 level in non-survivors vs. survivors and the outcome of the association between PTX3 and mortality were associated with sample size but not male proportion. AUC was associated with both sample size and male proportion. Conclusions PTX3 level was significantly higher in non-survivor compared to survivor patients with sepsis. Elevated PTX3 level was significantly associated with mortality. Furthermore, the level of PTX3 might predict patient mortality. |
| first_indexed | 2024-12-12T04:34:02Z |
| format | Article |
| id | doaj.art-be97aef9c49d4b4cbdfc22454dff8e7a |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-12T04:34:02Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-be97aef9c49d4b4cbdfc22454dff8e7a2022-12-22T00:38:01ZengBMCCritical Care1364-85352022-06-0126111210.1186/s13054-022-04032-xPentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysisGuobin Wang0Chunyan Jiang1Junjun Fang2Zhitao Li3Hongliu Cai4Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract Background The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. Methods Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case–control studies were extracted for the meta-analysis. Multivariate regression analysis was used to evaluate the correlation of the outcomes with sample size and male proportion. Results A total of 17 studies covering 3658 sepsis patients were included. PTX3 level was significantly higher in non-survivor compared to survivor patients (SMD (95% CI): −1.06 (−1.43, −0.69), P < 0.001). Increased PTX3 level was significantly associated with mortality (HR (95% CI): 2.09 (1.55, 2.81), P < 0.001). PTX3 showed good predictive capability for mortality (AUC:ES (95% CI): 0.73 (0.70, 0.77), P < 0.001). The outcome comparing PTX3 level in non-survivors vs. survivors and the outcome of the association between PTX3 and mortality were associated with sample size but not male proportion. AUC was associated with both sample size and male proportion. Conclusions PTX3 level was significantly higher in non-survivor compared to survivor patients with sepsis. Elevated PTX3 level was significantly associated with mortality. Furthermore, the level of PTX3 might predict patient mortality.https://doi.org/10.1186/s13054-022-04032-xPentraxin-3SepsisMortalityAUCMeta-analysis |
| spellingShingle | Guobin Wang Chunyan Jiang Junjun Fang Zhitao Li Hongliu Cai Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis Critical Care Pentraxin-3 Sepsis Mortality AUC Meta-analysis |
| title | Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis |
| title_full | Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis |
| title_fullStr | Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis |
| title_full_unstemmed | Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis |
| title_short | Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis |
| title_sort | pentraxin 3 as a predictive marker of mortality in sepsis an updated systematic review and meta analysis |
| topic | Pentraxin-3 Sepsis Mortality AUC Meta-analysis |
| url | https://doi.org/10.1186/s13054-022-04032-x |
| work_keys_str_mv | AT guobinwang pentraxin3asapredictivemarkerofmortalityinsepsisanupdatedsystematicreviewandmetaanalysis AT chunyanjiang pentraxin3asapredictivemarkerofmortalityinsepsisanupdatedsystematicreviewandmetaanalysis AT junjunfang pentraxin3asapredictivemarkerofmortalityinsepsisanupdatedsystematicreviewandmetaanalysis AT zhitaoli pentraxin3asapredictivemarkerofmortalityinsepsisanupdatedsystematicreviewandmetaanalysis AT hongliucai pentraxin3asapredictivemarkerofmortalityinsepsisanupdatedsystematicreviewandmetaanalysis |