Histopathological analysis of the correlation between uveal melanomas and retinal tissue
AIM: To analyze the impacts of the shape of uveal melanoma on retinal structure.<p>METHODS: Histopathological sections and clinical data from patients with uveal melanoma were retrospectively observed and analyzed, and key indicators including the tumor's shape, size, height-to-base ratio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2020-02-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2020/2/202002002.pdf |
| _version_ | 1818047604122976256 |
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| author | Ju Zhang Wen-Bin Wei Bin Li Xiao-Lin Xu Jost B Jonas |
| author_facet | Ju Zhang Wen-Bin Wei Bin Li Xiao-Lin Xu Jost B Jonas |
| author_sort | Ju Zhang |
| collection | DOAJ |
| description | AIM: To analyze the impacts of the shape of uveal melanoma on retinal structure.<p>METHODS: Histopathological sections and clinical data from patients with uveal melanoma were retrospectively observed and analyzed, and key indicators including the tumor's shape, size, height-to-base ratio, retinal thinning and retinal invasion were analyzed.<p>RESULTS: The study included 102 patients(102 eyes)with a mean age of 45.6±12.4 years, with 76(75%)uveal melanomas showing the spindle cell type, 6(6%)showing the epitheloid cell type, 16(16%)showing the mixed cell type and 4(4%)showing predominantly other cell types. Differentiated by tumor locations: 3 cases of ciliary body melanoma(2.9%), 28 cases of ciliary body and choroid melanoma(27.5%), 71 cases of choroid melanoma(69.6%). Retinal thinning was detected in 43(43%)eyes and retinal invasion by the tumor cells in 86(84%)eyes. Maximal tumor height ranged between 1.2 and 15.6(mean: 8.3±3.6)mm, and mean maximal tumor base diameter was 17.3±6.5(range: 4.8-31.2)mm. Mean <i>R</i>-value as ratio of tumor peak height to maximal tumor base diameter was 0.53±0.32. Mean <i>R</i>-value was significantly higher in the group with retinal thinning(<i>n</i>=43)than in the group without retinal thinning(<i>n</i>=59)(0.69±0.31 <i>vs</i> 0.42±0.27; <i>P</i><0.01). <i>R</i>-value was slightly, however statistically not significantly higher in the group with retinal tumor invasion(<i>n</i>=86)than without retinal tumor invasion(<i>n</i>=16)(0.56±0.33 <i>vs</i> 0.41±0.25; <i>P</i>=0.09).<p>CONCLUSION: A high <i>R</i>-value indicating a prominent tumor is associated with tissue thinning in the adjacent retina, and marginally significantly with intra-retinal tumor cell invasion. Shape of uveal melanomas's corss section is of importance for the secondary involvement of the adjacent retina. |
| first_indexed | 2024-12-10T10:08:26Z |
| format | Article |
| id | doaj.art-be97f8eea7bf4340a14ba1b7727abcbe |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-10T10:08:26Z |
| publishDate | 2020-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-be97f8eea7bf4340a14ba1b7727abcbe2022-12-22T01:53:12ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-02-0120219720210.3980/j.issn.1672-5123.2020.2.02Histopathological analysis of the correlation between uveal melanomas and retinal tissueJu Zhang0Wen-Bin Wei1Bin Li2Xiao-Lin Xu3Jost B Jonas4Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Intraocular Tumor Diagnosis and Treatment Key Laboratory, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Intraocular Tumor Diagnosis and Treatment Key Laboratory, Beijing 100730, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Intraocular Tumor Diagnosis and Treatment Key Laboratory, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, ChinaBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Intraocular Tumor Diagnosis and Treatment Key Laboratory, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, ChinaDepartment of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim 69115, GermanyAIM: To analyze the impacts of the shape of uveal melanoma on retinal structure.<p>METHODS: Histopathological sections and clinical data from patients with uveal melanoma were retrospectively observed and analyzed, and key indicators including the tumor's shape, size, height-to-base ratio, retinal thinning and retinal invasion were analyzed.<p>RESULTS: The study included 102 patients(102 eyes)with a mean age of 45.6±12.4 years, with 76(75%)uveal melanomas showing the spindle cell type, 6(6%)showing the epitheloid cell type, 16(16%)showing the mixed cell type and 4(4%)showing predominantly other cell types. Differentiated by tumor locations: 3 cases of ciliary body melanoma(2.9%), 28 cases of ciliary body and choroid melanoma(27.5%), 71 cases of choroid melanoma(69.6%). Retinal thinning was detected in 43(43%)eyes and retinal invasion by the tumor cells in 86(84%)eyes. Maximal tumor height ranged between 1.2 and 15.6(mean: 8.3±3.6)mm, and mean maximal tumor base diameter was 17.3±6.5(range: 4.8-31.2)mm. Mean <i>R</i>-value as ratio of tumor peak height to maximal tumor base diameter was 0.53±0.32. Mean <i>R</i>-value was significantly higher in the group with retinal thinning(<i>n</i>=43)than in the group without retinal thinning(<i>n</i>=59)(0.69±0.31 <i>vs</i> 0.42±0.27; <i>P</i><0.01). <i>R</i>-value was slightly, however statistically not significantly higher in the group with retinal tumor invasion(<i>n</i>=86)than without retinal tumor invasion(<i>n</i>=16)(0.56±0.33 <i>vs</i> 0.41±0.25; <i>P</i>=0.09).<p>CONCLUSION: A high <i>R</i>-value indicating a prominent tumor is associated with tissue thinning in the adjacent retina, and marginally significantly with intra-retinal tumor cell invasion. Shape of uveal melanomas's corss section is of importance for the secondary involvement of the adjacent retina.http://ies.ijo.cn/cn_publish/2020/2/202002002.pdfuveal neoplasmapathologymelanoma |
| spellingShingle | Ju Zhang Wen-Bin Wei Bin Li Xiao-Lin Xu Jost B Jonas Histopathological analysis of the correlation between uveal melanomas and retinal tissue Guoji Yanke Zazhi uveal neoplasma pathology melanoma |
| title | Histopathological analysis of the correlation between uveal melanomas and retinal tissue |
| title_full | Histopathological analysis of the correlation between uveal melanomas and retinal tissue |
| title_fullStr | Histopathological analysis of the correlation between uveal melanomas and retinal tissue |
| title_full_unstemmed | Histopathological analysis of the correlation between uveal melanomas and retinal tissue |
| title_short | Histopathological analysis of the correlation between uveal melanomas and retinal tissue |
| title_sort | histopathological analysis of the correlation between uveal melanomas and retinal tissue |
| topic | uveal neoplasma pathology melanoma |
| url | http://ies.ijo.cn/cn_publish/2020/2/202002002.pdf |
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