Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats
Purpose: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded as a cognitive enhancer, the aim of this study was to investigate the effects of chronic moda...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2015-12-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-19-4-220.pdf |
| _version_ | 1818931535212969984 |
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| author | Wen-Wen Yan Li-Hua Yao Chong Chen Hai-Xia Wang Chu-Hua Li Jun-Ni Huang Peng Xiao Cheng-Yi Liu |
| author_facet | Wen-Wen Yan Li-Hua Yao Chong Chen Hai-Xia Wang Chu-Hua Li Jun-Ni Huang Peng Xiao Cheng-Yi Liu |
| author_sort | Wen-Wen Yan |
| collection | DOAJ |
| description | Purpose: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded as a cognitive enhancer, the aim of this study was to investigate the effects of chronic modafinil administration on behavioral learning in healthy adult rats. Methods: Y-maze training was used to assess learning performance, and the whole-cell patch clamp technique was used to assess synaptic transmission in pyramidal neurons of the hippocampal CA1 region of rats. Results: Intraperitoneal administration of modafinil at 200 mg/kg or 300 mg/kg significantly improved learning performance. Furthermore, perfusion with 1mM modafinil enhanced the frequency and amplitude of spontaneous postsynaptic currents and spontaneous excitatory postsynaptic currents in CA1 pyramidal neurons in hippocampal slices. However, the frequency and amplitude of spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons were inhibited by treatment with 1mM modafinil. Conclusions: These results indicate that modafinil improves learning and memory in rats possibly by enhancing glutamatergic excitatory synaptic transmission and inhibiting GABAergic (gamma-aminobutyric acid-ergic) inhibitory synaptic transmission. |
| first_indexed | 2024-12-20T04:18:08Z |
| format | Article |
| id | doaj.art-be987529eb064a1eb0ea0c87c12399d9 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-20T04:18:08Z |
| publishDate | 2015-12-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-be987529eb064a1eb0ea0c87c12399d92022-12-21T19:53:43ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312015-12-0119422022710.5213/inj.2015.19.4.220553Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in RatsWen-Wen Yan0Li-Hua Yao1Chong Chen2Hai-Xia Wang3Chu-Hua Li4Jun-Ni Huang5Peng Xiao6Cheng-Yi Liu7 School of Life Science, South China Normal University, Guangzhou, China School of Life Science, Jiangxi Science & Technology Normal University, Nanchang, China School of Life Science, Jiangxi Science & Technology Normal University, Nanchang, China School of Sport Science, South China Normal University, Guangzhou, China School of Life Science, South China Normal University, Guangzhou, China School of Life Science, South China Normal University, Guangzhou, China School of Life Science, South China Normal University, Guangzhou, China School of Sport Science, South China Normal University, Guangzhou, ChinaPurpose: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded as a cognitive enhancer, the aim of this study was to investigate the effects of chronic modafinil administration on behavioral learning in healthy adult rats. Methods: Y-maze training was used to assess learning performance, and the whole-cell patch clamp technique was used to assess synaptic transmission in pyramidal neurons of the hippocampal CA1 region of rats. Results: Intraperitoneal administration of modafinil at 200 mg/kg or 300 mg/kg significantly improved learning performance. Furthermore, perfusion with 1mM modafinil enhanced the frequency and amplitude of spontaneous postsynaptic currents and spontaneous excitatory postsynaptic currents in CA1 pyramidal neurons in hippocampal slices. However, the frequency and amplitude of spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons were inhibited by treatment with 1mM modafinil. Conclusions: These results indicate that modafinil improves learning and memory in rats possibly by enhancing glutamatergic excitatory synaptic transmission and inhibiting GABAergic (gamma-aminobutyric acid-ergic) inhibitory synaptic transmission.http://www.einj.org/upload/pdf/inj-19-4-220.pdfModafinilLearningCA1 Region, HippocampalSynaptic TransmissionSynaptic Potentials |
| spellingShingle | Wen-Wen Yan Li-Hua Yao Chong Chen Hai-Xia Wang Chu-Hua Li Jun-Ni Huang Peng Xiao Cheng-Yi Liu Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats International Neurourology Journal Modafinil Learning CA1 Region, Hippocampal Synaptic Transmission Synaptic Potentials |
| title | Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats |
| title_full | Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats |
| title_fullStr | Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats |
| title_full_unstemmed | Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats |
| title_short | Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats |
| title_sort | effects of modafinil on behavioral learning and hippocampal synaptic transmission in rats |
| topic | Modafinil Learning CA1 Region, Hippocampal Synaptic Transmission Synaptic Potentials |
| url | http://www.einj.org/upload/pdf/inj-19-4-220.pdf |
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