Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex

Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex

Soluble guanylyl cyclase (GC1) and oxido-reductase thioredoxin (Trx1) form a complex that mediates two NO signaling pathways as a function of the redox state of cells. Under physiological conditions, reduced Trx1 (rTrx1) supports the canonical NO-GC1-cGMP pathway by protecting GC1 activity from thio...

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Bibliographic Details
Main Authors: Chuanlong Cui, Ping Shu, Tanaz Sadeghian, Waqas Younis, Hong Li, Annie Beuve
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antioxidants
Subjects:
thioredoxin
oxidative stress
NO
transnitrosation
mimetic peptide
soluble guanylyl cyclase
Online Access:https://www.mdpi.com/2076-3921/12/4/906

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