Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases
Alternative pre-mRNA splicing plays a very important role in expanding protein diversity as it generates numerous transcripts from a single protein-coding gene. Therefore, alterations lead this process to neurological human disorders, including Alzheimer’s and Parkinson’s diseases. Moreover, accumul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/8/1272 |
| _version_ | 1797523792590798848 |
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| author | Eglė Jakubauskienė Arvydas Kanopka |
| author_facet | Eglė Jakubauskienė Arvydas Kanopka |
| author_sort | Eglė Jakubauskienė |
| collection | DOAJ |
| description | Alternative pre-mRNA splicing plays a very important role in expanding protein diversity as it generates numerous transcripts from a single protein-coding gene. Therefore, alterations lead this process to neurological human disorders, including Alzheimer’s and Parkinson’s diseases. Moreover, accumulating evidence indicates that the splicing machinery highly contributes to the cells’ ability to adapt to different altered cellular microenvironments, such as hypoxia. Hypoxia is known to have an effect on the expression of proteins involved in a multiple of biological processes, such as erythropoiesis, angiogenesis, and neurogenesis, and is one of the important risk factors in neuropathogenesis. In this review, we discuss the current knowledge of alternatively spliced genes, which, as it is reported, are associated with Alzheimer’s and Parkinson’s diseases. Additionally, we highlight the possible influence of cellular hypoxic microenvironment for the formation of mRNA isoforms contributing to the development of these neurodegenerative diseases. |
| first_indexed | 2024-03-10T08:47:09Z |
| format | Article |
| id | doaj.art-be9b78c758174d3dbd37ff4aab563ebc |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T08:47:09Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-be9b78c758174d3dbd37ff4aab563ebc2023-11-22T07:46:59ZengMDPI AGGenes2073-44252021-08-01128127210.3390/genes12081272Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s DiseasesEglė Jakubauskienė0Arvydas Kanopka1Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, LithuaniaInstitute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, LithuaniaAlternative pre-mRNA splicing plays a very important role in expanding protein diversity as it generates numerous transcripts from a single protein-coding gene. Therefore, alterations lead this process to neurological human disorders, including Alzheimer’s and Parkinson’s diseases. Moreover, accumulating evidence indicates that the splicing machinery highly contributes to the cells’ ability to adapt to different altered cellular microenvironments, such as hypoxia. Hypoxia is known to have an effect on the expression of proteins involved in a multiple of biological processes, such as erythropoiesis, angiogenesis, and neurogenesis, and is one of the important risk factors in neuropathogenesis. In this review, we discuss the current knowledge of alternatively spliced genes, which, as it is reported, are associated with Alzheimer’s and Parkinson’s diseases. Additionally, we highlight the possible influence of cellular hypoxic microenvironment for the formation of mRNA isoforms contributing to the development of these neurodegenerative diseases.https://www.mdpi.com/2073-4425/12/8/1272neurodegenerative diseasesAlzheimer’s diseaseParkinson’s diseasealternative pre-mRNA splicingsplicing factorshypoxia |
| spellingShingle | Eglė Jakubauskienė Arvydas Kanopka Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases Genes neurodegenerative diseases Alzheimer’s disease Parkinson’s disease alternative pre-mRNA splicing splicing factors hypoxia |
| title | Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases |
| title_full | Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases |
| title_fullStr | Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases |
| title_full_unstemmed | Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases |
| title_short | Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases |
| title_sort | alternative splicing and hypoxia puzzle in alzheimer s and parkinson s diseases |
| topic | neurodegenerative diseases Alzheimer’s disease Parkinson’s disease alternative pre-mRNA splicing splicing factors hypoxia |
| url | https://www.mdpi.com/2073-4425/12/8/1272 |
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