Extra-Neural Metastases of Malignant Gliomas: Myth or Reality?
Malignant gliomas account for approximately 60% of all primary brain tumors in adults. Prognosis for these patients has not significantly changed in recent years—despite debulking surgery, radiotherapy and cytotoxic chemotherapy—with a median survival of 9–12 months. Virtually no patients are cured...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-01-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/3/1/461/ |
| _version_ | 1797762006275588096 |
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| author | Patrick Beauchesne |
| author_facet | Patrick Beauchesne |
| author_sort | Patrick Beauchesne |
| collection | DOAJ |
| description | Malignant gliomas account for approximately 60% of all primary brain tumors in adults. Prognosis for these patients has not significantly changed in recent years—despite debulking surgery, radiotherapy and cytotoxic chemotherapy—with a median survival of 9–12 months. Virtually no patients are cured of their illness. Malignant gliomas are usually locally invasive tumors, though extra-neural metastases can sometimes occur late in the course of the disease (median of two years). They generally appear after craniotomy although spontaneous metastases have also been reported. The incidence of these metastases from primary intra-cranial malignant gliomas is low; it is estimated at less than 2% of all cases. Extra-neural metastases from gliomas frequently occur late in the course of the disease (median of two years), and generally appear after craniotomy, but spontaneous metastases have also been reported. Malignant glioma metastases usually involve the regional lymph nodes, lungs and pleural cavity, and occasionally the bone and liver. In this review, we present three cases of extra-neural metastasis of malignant gliomas from our department, summarize the main reported cases in literature, and try to understand the mechanisms underlying these systemic metastases. |
| first_indexed | 2024-03-12T19:22:10Z |
| format | Article |
| id | doaj.art-be9f686322174c90ab748cb9aa920e3d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:22:10Z |
| publishDate | 2011-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-be9f686322174c90ab748cb9aa920e3d2023-08-02T05:07:08ZengMDPI AGCancers2072-66942011-01-013146147710.3390/cancers3010461Extra-Neural Metastases of Malignant Gliomas: Myth or Reality?Patrick BeauchesneMalignant gliomas account for approximately 60% of all primary brain tumors in adults. Prognosis for these patients has not significantly changed in recent years—despite debulking surgery, radiotherapy and cytotoxic chemotherapy—with a median survival of 9–12 months. Virtually no patients are cured of their illness. Malignant gliomas are usually locally invasive tumors, though extra-neural metastases can sometimes occur late in the course of the disease (median of two years). They generally appear after craniotomy although spontaneous metastases have also been reported. The incidence of these metastases from primary intra-cranial malignant gliomas is low; it is estimated at less than 2% of all cases. Extra-neural metastases from gliomas frequently occur late in the course of the disease (median of two years), and generally appear after craniotomy, but spontaneous metastases have also been reported. Malignant glioma metastases usually involve the regional lymph nodes, lungs and pleural cavity, and occasionally the bone and liver. In this review, we present three cases of extra-neural metastasis of malignant gliomas from our department, summarize the main reported cases in literature, and try to understand the mechanisms underlying these systemic metastases.http://www.mdpi.com/2072-6694/3/1/461/extraneural metastasismalignant gliomasradiotherapychemotherapyneurosurgery |
| spellingShingle | Patrick Beauchesne Extra-Neural Metastases of Malignant Gliomas: Myth or Reality? Cancers extraneural metastasis malignant gliomas radiotherapy chemotherapy neurosurgery |
| title | Extra-Neural Metastases of Malignant Gliomas: Myth or Reality? |
| title_full | Extra-Neural Metastases of Malignant Gliomas: Myth or Reality? |
| title_fullStr | Extra-Neural Metastases of Malignant Gliomas: Myth or Reality? |
| title_full_unstemmed | Extra-Neural Metastases of Malignant Gliomas: Myth or Reality? |
| title_short | Extra-Neural Metastases of Malignant Gliomas: Myth or Reality? |
| title_sort | extra neural metastases of malignant gliomas myth or reality |
| topic | extraneural metastasis malignant gliomas radiotherapy chemotherapy neurosurgery |
| url | http://www.mdpi.com/2072-6694/3/1/461/ |
| work_keys_str_mv | AT patrickbeauchesne extraneuralmetastasesofmalignantgliomasmythorreality |