SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model

SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model

Small animal models that accurately model pathogenesis of SARS-CoV-2 variants are required for ongoing research efforts. We modified our human immune system mouse model to support replication of SARS-CoV-2 by implantation of human lung tissue into the mice to create TKO-BLT-Lung (L) mice and compare...

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Bibliographic Details
Main Authors: Yunyun Di, Jocelyne Lew, Una Goncin, Anna Radomska, Saurav S. Rout, Bridget E. T. Gray, Steven Machtaler, Darryl Falzarano, Kerry J. Lavender
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
SARS-CoV-2
humanized mice
variants of concern
immunity
Online Access:https://www.mdpi.com/1999-4915/14/10/2272

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