Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response
The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. I...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3325 |
| _version_ | 1797528090270760960 |
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| author | Konsta Kukkonen Sinja Taavitsainen Laura Huhtala Joonas Uusi-Makela Kirsi J. Granberg Matti Nykter Alfonso Urbanucci |
| author_facet | Konsta Kukkonen Sinja Taavitsainen Laura Huhtala Joonas Uusi-Makela Kirsi J. Granberg Matti Nykter Alfonso Urbanucci |
| author_sort | Konsta Kukkonen |
| collection | DOAJ |
| description | The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. In this review, we collect and assess evidence on the contribution of chromatin and epigenetic dysregulation in prostate cancer. We highlight important mechanisms leading to prostate carcinogenesis, the emergence of castration-resistance upon treatment with androgen deprivation therapy, and resistance to antiandrogens. We examine in particular the contribution of chromatin structure and epigenetics to cell lineage commitment, which is dysregulated during tumorigenesis, and cell plasticity, which is altered during tumor progression. |
| first_indexed | 2024-03-10T09:53:10Z |
| format | Article |
| id | doaj.art-bea0c4c9b8584c4b83b9392617477652 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:53:10Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bea0c4c9b8584c4b83b93926174776522023-11-22T02:36:08ZengMDPI AGCancers2072-66942021-07-011313332510.3390/cancers13133325Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic ResponseKonsta Kukkonen0Sinja Taavitsainen1Laura Huhtala2Joonas Uusi-Makela3Kirsi J. Granberg4Matti Nykter5Alfonso Urbanucci6Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, 33520 Tampere, FinlandProstate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, 33520 Tampere, FinlandProstate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, 33520 Tampere, FinlandProstate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, 33520 Tampere, FinlandProstate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, 33520 Tampere, FinlandProstate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, 33520 Tampere, FinlandDepartment of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, NorwayThe dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer. In this review, we collect and assess evidence on the contribution of chromatin and epigenetic dysregulation in prostate cancer. We highlight important mechanisms leading to prostate carcinogenesis, the emergence of castration-resistance upon treatment with androgen deprivation therapy, and resistance to antiandrogens. We examine in particular the contribution of chromatin structure and epigenetics to cell lineage commitment, which is dysregulated during tumorigenesis, and cell plasticity, which is altered during tumor progression.https://www.mdpi.com/2072-6694/13/13/3325prostate cancerepigeneticschromatinlineage commitmentlineage plasticitychromatin-associated factors |
| spellingShingle | Konsta Kukkonen Sinja Taavitsainen Laura Huhtala Joonas Uusi-Makela Kirsi J. Granberg Matti Nykter Alfonso Urbanucci Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response Cancers prostate cancer epigenetics chromatin lineage commitment lineage plasticity chromatin-associated factors |
| title | Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response |
| title_full | Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response |
| title_fullStr | Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response |
| title_full_unstemmed | Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response |
| title_short | Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response |
| title_sort | chromatin and epigenetic dysregulation of prostate cancer development progression and therapeutic response |
| topic | prostate cancer epigenetics chromatin lineage commitment lineage plasticity chromatin-associated factors |
| url | https://www.mdpi.com/2072-6694/13/13/3325 |
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