Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/5/774 |
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| author | Erasmo Zamarrón-Licona José Manuel Rodríguez-Pérez Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Manuel Alfonso Baños-González Verónica Marusa Borgonio-Cuadra Nonanzit Pérez-Hernández |
| author_facet | Erasmo Zamarrón-Licona José Manuel Rodríguez-Pérez Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Manuel Alfonso Baños-González Verónica Marusa Borgonio-Cuadra Nonanzit Pérez-Hernández |
| author_sort | Erasmo Zamarrón-Licona |
| collection | DOAJ |
| description | Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events in asymptomatic individuals diagnosed with subclinical atherosclerosis (CAC > 0). In this study, our aim is to evaluate the participation of two polymorphisms of the <i>PCSK9</i> gene as genetic markers for developing subclinical atherosclerosis and cardiometabolic risk factors in asymptomatic individuals. Methods: We analyzed two PCSK9 polymorphisms (rs2479409 and rs615563) in 394 individuals with subclinical atherosclerosis and 1102 healthy controls using real time- polymerase chain reaction (PCR). Results: Under various inheritance models adjusted for different confounding factors, the rs2479409 polymorphism was associated with an increased risk of developing subclinical atherosclerosis (OR = 1.53, P recessive = 0.041). Both polymorphisms were significantly associated with several cardiometabolic parameters. Conclusions: Our data suggest that rs2479409 polymorphism could be envisaged as a risk marker for subclinical atherosclerosis. |
| first_indexed | 2024-03-10T11:58:16Z |
| format | Article |
| id | doaj.art-bea25daab7f54f7d837f0ff479d11468 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T11:58:16Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bea25daab7f54f7d837f0ff479d114682023-11-21T17:09:40ZengMDPI AGDiagnostics2075-44182021-04-0111577410.3390/diagnostics11050774Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA ProjectErasmo Zamarrón-Licona0José Manuel Rodríguez-Pérez1Rosalinda Posadas-Sánchez2Gilberto Vargas-Alarcón3Manuel Alfonso Baños-González4Verónica Marusa Borgonio-Cuadra5Nonanzit Pérez-Hernández6Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, MexicoDepartamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, MexicoCentro de Investigación y Posgrado, División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86150, MexicoDepartamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra, Ciudad de México 14389, MexicoDepartamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, MexicoBackground: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events in asymptomatic individuals diagnosed with subclinical atherosclerosis (CAC > 0). In this study, our aim is to evaluate the participation of two polymorphisms of the <i>PCSK9</i> gene as genetic markers for developing subclinical atherosclerosis and cardiometabolic risk factors in asymptomatic individuals. Methods: We analyzed two PCSK9 polymorphisms (rs2479409 and rs615563) in 394 individuals with subclinical atherosclerosis and 1102 healthy controls using real time- polymerase chain reaction (PCR). Results: Under various inheritance models adjusted for different confounding factors, the rs2479409 polymorphism was associated with an increased risk of developing subclinical atherosclerosis (OR = 1.53, P recessive = 0.041). Both polymorphisms were significantly associated with several cardiometabolic parameters. Conclusions: Our data suggest that rs2479409 polymorphism could be envisaged as a risk marker for subclinical atherosclerosis.https://www.mdpi.com/2075-4418/11/5/774subclinical atherosclerosisproprotein convertase subtilisin/kexin type 9vascular diseasescoronary artery calciumgenetic associationpolymorphisms |
| spellingShingle | Erasmo Zamarrón-Licona José Manuel Rodríguez-Pérez Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Manuel Alfonso Baños-González Verónica Marusa Borgonio-Cuadra Nonanzit Pérez-Hernández Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project Diagnostics subclinical atherosclerosis proprotein convertase subtilisin/kexin type 9 vascular diseases coronary artery calcium genetic association polymorphisms |
| title | Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project |
| title_full | Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project |
| title_fullStr | Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project |
| title_full_unstemmed | Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project |
| title_short | Variants of <i>PCSK9</i> Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project |
| title_sort | variants of i pcsk9 i gene are associated with subclinical atherosclerosis and cardiometabolic parameters in mexicans the gea project |
| topic | subclinical atherosclerosis proprotein convertase subtilisin/kexin type 9 vascular diseases coronary artery calcium genetic association polymorphisms |
| url | https://www.mdpi.com/2075-4418/11/5/774 |
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