KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation

KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation

Glioblastoma (GB) is the most aggressive tumor of the central nervous system (CNS), characterized by excessive proliferation, necrosis and invasiveness. The survival rate for patients with GB still remains low. Angiogenesis and apoptosis play a key role in the development of GB. Thus, the modulation...

Full description

Bibliographic Details
Main Authors:	Sarah Adriana Scuderi, Giovanna Casili, Alessio Ardizzone, Stefano Forte, Lorenzo Colarossi, Serena Sava, Irene Paterniti, Emanuela Esposito, Salvatore Cuzzocrea, Michela Campolo
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Cancers
Subjects:	glioblastoma (GB) prolyl-oligopeptidase (POP) vascular endothelial growth factor (VEGF) transforming growth factor-β (TGF-β) angiopoietin (Ang) endothelial nitric oxide synthase (eNOS)
Online Access:	https://www.mdpi.com/2072-6694/13/14/3444

Similar Items

The Inhibition of Prolyl Oligopeptidase as New Target to Counteract Chronic Venous Insufficiency: Findings in a Mouse Model
by: Giovanna Casili, et al.
Published: (2020-12-01)

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
by: Maija Toppila, et al.
Published: (2023-06-01)

Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro
by: Laura Cucinotta, et al.
Published: (2023-08-01)

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice
by: Elena Puris, et al.
Published: (2022-06-01)

The Protective Role of Prolyl Oligopeptidase (POP) Inhibition in Kidney Injury Induced by Renal Ischemia–Reperfusion
by: Giovanna Casili, et al.
Published: (2021-11-01)

Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia
by: Èlia Vila, et al.
Published: (2023-03-01)

Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase
by: Jasmin Gattringer, et al.
Published: (2021-07-01)

Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes
by: Zhengmi He, et al.
Published: (2020-06-01)

Corn gluten meal peptides inhibit prolyl oligopeptidase and modulate α-synuclein aggregation in KCl-treated SH-SY5Y cells
by: Phiromya Chanajon, et al.
Published: (2023-05-01)

Crystal Structure of Inhibitor-Bound Bacterial Oligopeptidase B in the Closed State: Similarity and Difference between Protozoan and Bacterial Enzymes
by: Dmitry E. Petrenko, et al.
Published: (2023-01-01)

Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation
by: Vladimir V. Britikov, et al.
Published: (2022-05-01)

Abnormal Expression of Prolyl Oligopeptidase (POP) and Its Catalytic Products Ac-SDKP Contributes to the Ovarian Fibrosis Change in Polycystic Ovary Syndrome (PCOS) Mice
by: Suo Han, et al.
Published: (2023-07-01)

Study on the Phototoxicity and Antitumor Activity of Plant Extracts from Tanacetum vulgare L., Epilobium parviflorum Schreb., and Geranium sanguineum L.
by: Inna Sulikovska, et al.
Published: (2023-03-01)

Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications
by: Anis Baharin, et al.
Published: (2022-05-01)

Prolyl oligopeptidase activity (POP) in early stage and medicated schizophrenia and in an animal model for schizophrenia study: In vivo effects of psychopharmacological substances on enzyme activity
by: Lucas A.N. Marins, et al.
Published: (2023-06-01)

Comparison of the Effects of Native and Commercial Probiotic on Gluten Degradation
by: Elham Rostami, et al.
Published: (2021-11-01)

Inhibition of Prolyl Oligopeptidase Prevents Consequences of Reperfusion following Intestinal Ischemia
by: Alessia Filippone, et al.
Published: (2021-09-01)

Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity
by: Indranil Sinha, et al.
Published: (2017-07-01)

Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease
by: Lucie Cahlíková, et al.
Published: (2021-08-01)

Exacerbation of Diabetic Retinopathy following Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor Administration: A Case Report
by: Nobuaki Ariyoshi, et al.
Published: (2024-03-01)

Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form
by: Yu Liu, et al.
Published: (2021-09-01)

Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis
by: Paola Pignata, et al.
Published: (2021-04-01)

Prolyl Endopeptidase-like Deficiency Associated with Growth Hormone Deficiency
by: Laura Sayol-Torres, et al.
Published: (2023-06-01)

L-mimosine and hypoxia can increase angiogenin production in dental pulp-derived cells
by: Klara Janjić, et al.
Published: (2017-05-01)

Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia
by: Nikolay N. Zolotov, et al.
Published: (2021-12-01)

Safety of proline‐specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97
by: EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), et al.
Published: (2017-02-01)

Evaluation of the Serum Level of Vascular Endothelial Growth Factor in Patients with Beta-Thalassemia Major and Sickle/Beta-Thalassemia, and its Correlation with Clinical and Laboratory Parameters
by: Sara Anmar Abdul Mohsin, et al.
Published: (2023-01-01)

REGULATION OF BONE MARROW ANGIOGENESIS BY OSTEOBLASTS DURING BONE DEVELOPMENT AND HOMEOSTASIS
by: Ernestina eSchipani, et al.
Published: (2013-07-01)

Prolyl Carboxypeptidase Mediates the C-Terminal Cleavage of (Pyr)-Apelin-13 in Human Umbilical Vein and Aortic Endothelial Cells
by: Emilie De Hert, et al.
Published: (2021-06-01)

How the Hinge Region Affects Interactions between the Catalytic and β-Propeller Domains in Oligopeptidase B
by: Vladimir I. Timofeev, et al.
Published: (2023-11-01)

Identification and characterization of an Aeromonas hydrophila oligopeptidase gene pepF negatively related to biofilm formation
by: Hechao Du, et al.
Published: (2016-09-01)

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity
by: Giuseppe Pollio, et al.
Published: (2008-07-01)

Editorial: Hypertension and Chronic Kidney Injury or Failure, Volume II
by: Zhengrong Guan, et al.
Published: (2022-01-01)

Effects of intravitreous injection on the expression of vascular endothelial growth inhibitor in vitreous of proliferative diabetic retinopathy
by: Rui Shi, et al.
Published: (2015-06-01)

Dimerization and thiol sensitivity of the salicylic acid binding thimet oligopeptidases TOP1 and TOP2 define their functions in redox-sensitive cellular pathways
by: Timothy James Westlake, et al.
Published: (2015-05-01)

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (<i>Mesembryanthemum crystallinum</i>)
by: Marta María Calvo, et al.
Published: (2022-05-01)

First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine
by: Dmitry E. Petrenko, et al.
Published: (2021-10-01)

Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice
by: Quoc-Viet Duong, et al.
Published: (2019-03-01)

Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis
by: Zeynep Tastan Eroglu, et al.
Published: (2018-12-01)

The Crystal Structure of Nα-p-tosyl-lysyl Chloromethylketone-Bound Oligopeptidase B from Serratia Proteamaculans Revealed a New Type of Inhibitor Binding
by: Vladimir I. Timofeev, et al.
Published: (2021-11-01)