Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome
Introduction Post-COVID syndrome (PCS) is a frequent phenomenon of patients who have suffered from an acute attack of COVID-19 infection, and it is characterized by a wide range of symptoms from different organs and systems including the musculoskeletal system (MSS). However, peculiarities of MSS le...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-10-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/Peculiarities-of-clinical-signs-course-and-treatment-of-musculoskeletal-system-lesions,172575,0,2.html |
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| author | Larysa Voloshyna Svitlana Smiyan Oleksandr Voloshyn Inna Buzdugan Olga Bukach Natalia Voloshynovych Oleksandra Doholich |
| author_facet | Larysa Voloshyna Svitlana Smiyan Oleksandr Voloshyn Inna Buzdugan Olga Bukach Natalia Voloshynovych Oleksandra Doholich |
| author_sort | Larysa Voloshyna |
| collection | DOAJ |
| description | Introduction
Post-COVID syndrome (PCS) is a frequent phenomenon of patients who have suffered from an acute attack of COVID-19 infection, and it is characterized by a wide range of symptoms from different organs and systems including the musculoskeletal system (MSS). However, peculiarities of MSS lesions have not been sufficiently studied to date, in particular, in the aspect of the therapeutic process. We aimed to investigate peculiarities of MSS lesions in patients with PCS.
Material and Methods
Observations were carried out in 142 patients with PCS and MSS lesions. The age of patients was 36–67 years. Up-to-date methods of disease verification were used. An acute period of COVID-19 in all the patients was of moderate severity without oxygen support.
Results
Musculoskeletal system lesions in patients with PCS were found to appear 1–4 weeks after the experienced acute period of COVID-19 infection. Against the background of significant arthralgia (100%) in 93 (65.5%) patients manifestations of acute arthritis were detected, the frequency of which increased with age. Musculoskeletal system lesions were found against the background of dominating PCS manifestations from the cardiovascular and digestive systems. Deterioration of the course and results of treatment of diseases caused by an age-related polymorbid background was determined. Certain difficulties in the treatment of MSS lesions by means of non-steroidal anti-inflammatory drugs and limitation in the use of glucocorticosteroids are caused by severe gastroduodenopathy and arterial hypertension. Long-term, up to 6 months, administration of L-arginine, L-carnitine and quercetin in the rehabilitation complex improved the overall results of treatment of PCS manifestations including arthropathy.
Conclusions
Musculoskeletal system lesions in patients with PCS are not the main constituent of this syndrome. Difficulties in the treatment of arthropathy are due to the signs of gastroduodenopathy and arterial hypertension. Additional administration of L-arginine, L-carnitine and quercetin is reasonable. |
| first_indexed | 2024-03-09T10:43:51Z |
| format | Article |
| id | doaj.art-bea6ce20af4241a49191318e15453048 |
| institution | Directory Open Access Journal |
| issn | 0034-6233 2084-9834 |
| language | English |
| last_indexed | 2024-03-09T10:43:51Z |
| publishDate | 2023-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj.art-bea6ce20af4241a49191318e154530482023-12-01T11:37:52ZengTermedia Publishing HouseRheumatology0034-62332084-98342023-10-0161533934410.5114/reum/172575172575Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndromeLarysa Voloshyna0https://orcid.org/0000-0003-2006-2914Svitlana Smiyan1https://orcid.org/0000-0001-5543-9895Oleksandr Voloshyn2https://orcid.org/0000-0003-2500-4705Inna Buzdugan3https://orcid.org/0000-0002-4599-2360Olga Bukach4https://orcid.org/0000-0001-7346-0559Natalia Voloshynovych5https://orcid.org/0000-0003-4733-0536Oleksandra Doholich6https://orcid.org/0000-0002-5309-2602Bucovinian State Medical University, State Medical Institute, Chernivtsi, UkraineDanylo Halytsky Lviv National Medical University, I. Horbachevsky Ternopil National Medical University, National Scientific Center “MD Strazhesko Institute of Cardiology”, UkraineBucovinian State Medical University, State Medical Institute, Chernivtsi, UkraineBucovinian State Medical University, State Medical Institute, Chernivtsi, UkraineBucovinian State Medical University, State Medical Institute, Chernivtsi, UkraineBucovinian State Medical University, State Medical Institute, Chernivtsi, UkraineBucovinian State Medical University, State Medical Institute, Chernivtsi, UkraineIntroduction Post-COVID syndrome (PCS) is a frequent phenomenon of patients who have suffered from an acute attack of COVID-19 infection, and it is characterized by a wide range of symptoms from different organs and systems including the musculoskeletal system (MSS). However, peculiarities of MSS lesions have not been sufficiently studied to date, in particular, in the aspect of the therapeutic process. We aimed to investigate peculiarities of MSS lesions in patients with PCS. Material and Methods Observations were carried out in 142 patients with PCS and MSS lesions. The age of patients was 36–67 years. Up-to-date methods of disease verification were used. An acute period of COVID-19 in all the patients was of moderate severity without oxygen support. Results Musculoskeletal system lesions in patients with PCS were found to appear 1–4 weeks after the experienced acute period of COVID-19 infection. Against the background of significant arthralgia (100%) in 93 (65.5%) patients manifestations of acute arthritis were detected, the frequency of which increased with age. Musculoskeletal system lesions were found against the background of dominating PCS manifestations from the cardiovascular and digestive systems. Deterioration of the course and results of treatment of diseases caused by an age-related polymorbid background was determined. Certain difficulties in the treatment of MSS lesions by means of non-steroidal anti-inflammatory drugs and limitation in the use of glucocorticosteroids are caused by severe gastroduodenopathy and arterial hypertension. Long-term, up to 6 months, administration of L-arginine, L-carnitine and quercetin in the rehabilitation complex improved the overall results of treatment of PCS manifestations including arthropathy. Conclusions Musculoskeletal system lesions in patients with PCS are not the main constituent of this syndrome. Difficulties in the treatment of arthropathy are due to the signs of gastroduodenopathy and arterial hypertension. Additional administration of L-arginine, L-carnitine and quercetin is reasonable.https://reu.termedia.pl/Peculiarities-of-clinical-signs-course-and-treatment-of-musculoskeletal-system-lesions,172575,0,2.htmlpost-covid syndromemusculoskeletal system lesionstreatment |
| spellingShingle | Larysa Voloshyna Svitlana Smiyan Oleksandr Voloshyn Inna Buzdugan Olga Bukach Natalia Voloshynovych Oleksandra Doholich Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome Rheumatology post-covid syndrome musculoskeletal system lesions treatment |
| title | Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome |
| title_full | Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome |
| title_fullStr | Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome |
| title_full_unstemmed | Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome |
| title_short | Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome |
| title_sort | peculiarities of clinical signs course and treatment of musculoskeletal system lesions in post covid syndrome |
| topic | post-covid syndrome musculoskeletal system lesions treatment |
| url | https://reu.termedia.pl/Peculiarities-of-clinical-signs-course-and-treatment-of-musculoskeletal-system-lesions,172575,0,2.html |
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