Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
Central nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability around the world. As the most common modification on ribonucleic acids (RNAs), N6-methyladenosine (m6A) modification ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.1013450/full |
| _version_ | 1828234820744904704 |
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| author | Mi Tian Lei Mao Li Zhang |
| author_facet | Mi Tian Lei Mao Li Zhang |
| author_sort | Mi Tian |
| collection | DOAJ |
| description | Central nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability around the world. As the most common modification on ribonucleic acids (RNAs), N6-methyladenosine (m6A) modification has recently attracted great attentions due to its functions in determining the fate of RNAs through changes in splicing, translation, degradation and stability. A large number of studies have suggested that m6A modification played an important role in brain development and involved in many neurological disorders, particularly in CNS injuries. It has been proposed that m6A modification could improve neurological impairment, inhibit apoptosis, suppress inflammation, reduce pyroptosis and attenuate ferroptosis in CNS injuries via different molecules including phosphatase and tensin homolog (PTEN), NLR family pyrin domain containing 3 (NLRP3), B-cell lymphoma 2 (Bcl-2), glutathione peroxidase 4 (GPX4), and long non-coding RNA (lncRNA). Therefore, m6A modification showed great promise as potential targets in CNS injuries. In this article, we present a review highlighting the role of m6A modification in CNS injuries. Hence, on the basis of these properties and effects, m6A modification may be developed as therapeutic agents for CNS injury patients. |
| first_indexed | 2024-04-12T20:02:41Z |
| format | Article |
| id | doaj.art-bea8211544a14b858b194fdef7c75049 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T20:02:41Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-bea8211544a14b858b194fdef7c750492022-12-22T03:18:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-09-011610.3389/fncel.2022.10134501013450Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuriesMi Tian0Lei Mao1Li Zhang2Department of Anesthesiology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu, ChinaDepartment of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, ChinaDepartment of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, ChinaCentral nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability around the world. As the most common modification on ribonucleic acids (RNAs), N6-methyladenosine (m6A) modification has recently attracted great attentions due to its functions in determining the fate of RNAs through changes in splicing, translation, degradation and stability. A large number of studies have suggested that m6A modification played an important role in brain development and involved in many neurological disorders, particularly in CNS injuries. It has been proposed that m6A modification could improve neurological impairment, inhibit apoptosis, suppress inflammation, reduce pyroptosis and attenuate ferroptosis in CNS injuries via different molecules including phosphatase and tensin homolog (PTEN), NLR family pyrin domain containing 3 (NLRP3), B-cell lymphoma 2 (Bcl-2), glutathione peroxidase 4 (GPX4), and long non-coding RNA (lncRNA). Therefore, m6A modification showed great promise as potential targets in CNS injuries. In this article, we present a review highlighting the role of m6A modification in CNS injuries. Hence, on the basis of these properties and effects, m6A modification may be developed as therapeutic agents for CNS injury patients.https://www.frontiersin.org/articles/10.3389/fncel.2022.1013450/fullcentral nervous system injuriesm6A modificationneurological impairmentapoptosisinflammationdownstream molecules |
| spellingShingle | Mi Tian Lei Mao Li Zhang Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries Frontiers in Cellular Neuroscience central nervous system injuries m6A modification neurological impairment apoptosis inflammation downstream molecules |
| title | Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries |
| title_full | Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries |
| title_fullStr | Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries |
| title_full_unstemmed | Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries |
| title_short | Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries |
| title_sort | crosstalk among n6 methyladenosine modification and rnas in central nervous system injuries |
| topic | central nervous system injuries m6A modification neurological impairment apoptosis inflammation downstream molecules |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.1013450/full |
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