Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature
Background: Adrenal cortex tumors (ACT) are extremely rare in children and adolescents. Only 0.2% of all the new cases of cancer diagnosed in the United Stated and Europe are adrenal cortex tumors. The international incidence is not well defined, since it differs demographically. Due to the rarity o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
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Instituto Nacional de Pediatría
2014-07-01
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| Series: | Acta Pediátrica de México |
| Subjects: | |
| Online Access: | http://ojs.actapediatrica.org.mx/index.php/APM/article/view/1027 |
| _version_ | 1818254205705519104 |
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| author | Paola de Baro-Álvarez Lizbeth García-García Olinka Reyes-Posada Jorge Cortes-Sauza Pedro A Sánchez-Márquez |
| author_facet | Paola de Baro-Álvarez Lizbeth García-García Olinka Reyes-Posada Jorge Cortes-Sauza Pedro A Sánchez-Márquez |
| author_sort | Paola de Baro-Álvarez |
| collection | DOAJ |
| description | Background: Adrenal cortex tumors (ACT) are extremely rare in children and adolescents. Only 0.2% of all the new cases of cancer diagnosed in the United Stated and Europe are adrenal cortex tumors. The international incidence is not well defined, since it differs demographically. Due to the rarity of these tumors in children, little is known about their natural history.
Case report: 11 months old female patient who developed, at the age of nine months,acne in forehead and thorax, also, weight gain, facial hair, apocrine activity, appearance of pubic hair, and hirsutism, increase of appetite, altered sleep-vigil cycle, increased height with accelerated growth velocity. From a biochemical standpoint, alterations in cortisol, showed an increase in morning and evening cortisol levels, as well as androgens. CT scan showed an adrenal mass on the right side not dependent of the kidney, which was completely resected. The histopathology report was of adenoma of the adrenal cortex. Currently, the patient is asymptomatic and is followed at the Endocrinology Service with dose reduction of steroid.
Conclusion: Because adrenal cortex tumors are extremely rare in children, a small percentage appears with virilization data and Cushing’s syndrome. For this reason, we should be aware of their existence in order to make the diagnosis and treat them as soon as possible. |
| first_indexed | 2024-12-12T16:52:16Z |
| format | Article |
| id | doaj.art-bea8ab06b82846e8969ee6b670a6aa93 |
| institution | Directory Open Access Journal |
| issn | 0186-2391 2395-8235 |
| language | Spanish |
| last_indexed | 2024-12-12T16:52:16Z |
| publishDate | 2014-07-01 |
| publisher | Instituto Nacional de Pediatría |
| record_format | Article |
| series | Acta Pediátrica de México |
| spelling | doaj.art-bea8ab06b82846e8969ee6b670a6aa932022-12-22T00:18:20ZspaInstituto Nacional de PediatríaActa Pediátrica de México0186-23912395-82352014-07-01351384410.18233/APM35No1pp33-38921Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literaturePaola de Baro-Álvarez0Lizbeth García-García1Olinka Reyes-Posada2Jorge Cortes-Sauza3Pedro A Sánchez-Márquez4Instituto Nacional de PediatríaHospital Infantil de TlaxcalaHospital Infantil de TlaxcalaHospital Infantil de TlaxcalaInstituto Nacional de PediatríaBackground: Adrenal cortex tumors (ACT) are extremely rare in children and adolescents. Only 0.2% of all the new cases of cancer diagnosed in the United Stated and Europe are adrenal cortex tumors. The international incidence is not well defined, since it differs demographically. Due to the rarity of these tumors in children, little is known about their natural history. Case report: 11 months old female patient who developed, at the age of nine months,acne in forehead and thorax, also, weight gain, facial hair, apocrine activity, appearance of pubic hair, and hirsutism, increase of appetite, altered sleep-vigil cycle, increased height with accelerated growth velocity. From a biochemical standpoint, alterations in cortisol, showed an increase in morning and evening cortisol levels, as well as androgens. CT scan showed an adrenal mass on the right side not dependent of the kidney, which was completely resected. The histopathology report was of adenoma of the adrenal cortex. Currently, the patient is asymptomatic and is followed at the Endocrinology Service with dose reduction of steroid. Conclusion: Because adrenal cortex tumors are extremely rare in children, a small percentage appears with virilization data and Cushing’s syndrome. For this reason, we should be aware of their existence in order to make the diagnosis and treat them as soon as possible.http://ojs.actapediatrica.org.mx/index.php/APM/article/view/1027Tumoradrenal cortexhirsutismcortisolandrogensvirilization |
| spellingShingle | Paola de Baro-Álvarez Lizbeth García-García Olinka Reyes-Posada Jorge Cortes-Sauza Pedro A Sánchez-Márquez Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature Acta Pediátrica de México Tumor adrenal cortex hirsutism cortisol androgens virilization |
| title | Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature |
| title_full | Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature |
| title_fullStr | Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature |
| title_full_unstemmed | Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature |
| title_short | Hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma. Report on a Mexican girl and review of the literature |
| title_sort | hypercortisolism and hyperandrogenism as manifestations of adrenal adenoma report on a mexican girl and review of the literature |
| topic | Tumor adrenal cortex hirsutism cortisol androgens virilization |
| url | http://ojs.actapediatrica.org.mx/index.php/APM/article/view/1027 |
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