Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that helps red blood cells work properly; it participates in the production of antioxidants and helps to defend cells against oxidative damage. With all this in mind, patients with G6PD deficiency may be very sensitive and vulnerable to different...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/21/6476 |
| _version_ | 1797467739085864960 |
|---|---|
| author | Ana Cicvarić Josipa Glavaš Tahtler Tea Vukoja Vukušić Ivančica Bekavac Slavica Kvolik |
| author_facet | Ana Cicvarić Josipa Glavaš Tahtler Tea Vukoja Vukušić Ivančica Bekavac Slavica Kvolik |
| author_sort | Ana Cicvarić |
| collection | DOAJ |
| description | Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that helps red blood cells work properly; it participates in the production of antioxidants and helps to defend cells against oxidative damage. With all this in mind, patients with G6PD deficiency may be very sensitive and vulnerable to different oxidative stressors, because they can cause some serious medical conditions of which hemolytic anemia is common in adults and severe jaundice in newborns. The most common triggers of hemolysis in G6PD deficiency are infections, medications, metabolic conditions such as diabetic ketoacidosis, hypothermia, and a very important item—surgical stress. During the operative period, the anesthetic goal is to reduce stress and monitor if the hemolysis occurs, and of course, treat it if it occurs. In our case, the combination of sevoflurane inhalation anesthesia with the addition of sufentanil proved to be safe and effective in the management of a child with G6PD deficiency. |
| first_indexed | 2024-03-09T18:58:01Z |
| format | Article |
| id | doaj.art-bea92224910b4b8e84fad8af6e5d7d90 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:58:01Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bea92224910b4b8e84fad8af6e5d7d902023-11-24T05:18:18ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121647610.3390/jcm11216476Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase DeficiencyAna Cicvarić0Josipa Glavaš Tahtler1Tea Vukoja Vukušić2Ivančica Bekavac3Slavica Kvolik4Department of Anesthesiology, Resuscitation, and ICU, Osijek University Hospital, 31000 Osijek, CroatiaDepartment of Anesthesiology, Resuscitation, and ICU, Osijek University Hospital, 31000 Osijek, CroatiaDepartment of Anesthesiology, Resuscitation, and ICU, Osijek University Hospital, 31000 Osijek, CroatiaDepartment of Pediatric Surgery, Osijek University Hospital, 31000 Osijek, CroatiaDepartment of Anesthesiology, Resuscitation, and ICU, Osijek University Hospital, 31000 Osijek, CroatiaGlucose-6-phosphate dehydrogenase (G6PD) is an enzyme that helps red blood cells work properly; it participates in the production of antioxidants and helps to defend cells against oxidative damage. With all this in mind, patients with G6PD deficiency may be very sensitive and vulnerable to different oxidative stressors, because they can cause some serious medical conditions of which hemolytic anemia is common in adults and severe jaundice in newborns. The most common triggers of hemolysis in G6PD deficiency are infections, medications, metabolic conditions such as diabetic ketoacidosis, hypothermia, and a very important item—surgical stress. During the operative period, the anesthetic goal is to reduce stress and monitor if the hemolysis occurs, and of course, treat it if it occurs. In our case, the combination of sevoflurane inhalation anesthesia with the addition of sufentanil proved to be safe and effective in the management of a child with G6PD deficiency.https://www.mdpi.com/2077-0383/11/21/6476glucose-6-phosphate dehydrogenase (G6PD)oxidative stressperioperative managementanesthesia managementpostoperative monitoring |
| spellingShingle | Ana Cicvarić Josipa Glavaš Tahtler Tea Vukoja Vukušić Ivančica Bekavac Slavica Kvolik Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency Journal of Clinical Medicine glucose-6-phosphate dehydrogenase (G6PD) oxidative stress perioperative management anesthesia management postoperative monitoring |
| title | Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency |
| title_full | Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency |
| title_fullStr | Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency |
| title_full_unstemmed | Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency |
| title_short | Management of Anesthesia and Perioperative Procedures in a Child with Glucose-6-Phosphate Dehydrogenase Deficiency |
| title_sort | management of anesthesia and perioperative procedures in a child with glucose 6 phosphate dehydrogenase deficiency |
| topic | glucose-6-phosphate dehydrogenase (G6PD) oxidative stress perioperative management anesthesia management postoperative monitoring |
| url | https://www.mdpi.com/2077-0383/11/21/6476 |
| work_keys_str_mv | AT anacicvaric managementofanesthesiaandperioperativeproceduresinachildwithglucose6phosphatedehydrogenasedeficiency AT josipaglavastahtler managementofanesthesiaandperioperativeproceduresinachildwithglucose6phosphatedehydrogenasedeficiency AT teavukojavukusic managementofanesthesiaandperioperativeproceduresinachildwithglucose6phosphatedehydrogenasedeficiency AT ivancicabekavac managementofanesthesiaandperioperativeproceduresinachildwithglucose6phosphatedehydrogenasedeficiency AT slavicakvolik managementofanesthesiaandperioperativeproceduresinachildwithglucose6phosphatedehydrogenasedeficiency |