Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection
Background: Glucantime is regarded as the first-line treatment of cutaneous leishmaniasis (CL); however, failure to treatment is a problem in many cases. Aim: The aim was to evaluate the therapeutic effect of glucantime in CL complicated with secondary bacterial infection compared to uncomplicated l...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=1;spage=37;epage=39;aulast=Sadeghian |
| _version_ | 1819230916100227072 |
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| author | G Sadeghian H Ziaei L Shirani Bidabadi A Zolfaghari Baghbaderani |
| author_facet | G Sadeghian H Ziaei L Shirani Bidabadi A Zolfaghari Baghbaderani |
| author_sort | G Sadeghian |
| collection | DOAJ |
| description | Background: Glucantime is regarded as the first-line treatment of cutaneous leishmaniasis (CL); however, failure to treatment is a problem in many cases. Aim: The aim was to evaluate the therapeutic effect of glucantime in CL complicated with secondary bacterial infection compared to uncomplicated lesions. Methods: This experimental study was performed in Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran. A total of 161 patients enrolled in the study had CL confirmed by positive smear of lesions. All the patients were treated with systemic glucantime for 3 weeks and followed for 2 months. Response to treatment was defined as loss of infiltration, reepithelization, and negative smear. Depending on the results of bacterial cultures, the lesions were divided into two groups and the efficacy of glucantime was compared. Results: A total of 123 patients (76.4%) were negative, and 38 patients (23.6%) were positive for secondary bacterial infection. In groups with negative bacterial culture response to treatment was 65% (80 patients) and in the other positive group, it was 31.6% (12 patients), with a difference (χ2 = 13.77, P < 0.01). Conclusion: Therapeutic effect of glucantime showed a decrease in CL lesions with secondary bacterial infection. Therefore, in the cases of unresponsiveness to treatment, the lesions should be evaluated for bacterial infection, before repeating the treatment. |
| first_indexed | 2024-12-23T11:36:40Z |
| format | Article |
| id | doaj.art-beaa73369cb84ecbbb92787159785978 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-23T11:36:40Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-beaa73369cb84ecbbb927871597859782022-12-21T17:48:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112011-01-01561373910.4103/0019-5154.77549Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infectionG SadeghianH ZiaeiL Shirani BidabadiA Zolfaghari BaghbaderaniBackground: Glucantime is regarded as the first-line treatment of cutaneous leishmaniasis (CL); however, failure to treatment is a problem in many cases. Aim: The aim was to evaluate the therapeutic effect of glucantime in CL complicated with secondary bacterial infection compared to uncomplicated lesions. Methods: This experimental study was performed in Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran. A total of 161 patients enrolled in the study had CL confirmed by positive smear of lesions. All the patients were treated with systemic glucantime for 3 weeks and followed for 2 months. Response to treatment was defined as loss of infiltration, reepithelization, and negative smear. Depending on the results of bacterial cultures, the lesions were divided into two groups and the efficacy of glucantime was compared. Results: A total of 123 patients (76.4%) were negative, and 38 patients (23.6%) were positive for secondary bacterial infection. In groups with negative bacterial culture response to treatment was 65% (80 patients) and in the other positive group, it was 31.6% (12 patients), with a difference (χ2 = 13.77, P < 0.01). Conclusion: Therapeutic effect of glucantime showed a decrease in CL lesions with secondary bacterial infection. Therefore, in the cases of unresponsiveness to treatment, the lesions should be evaluated for bacterial infection, before repeating the treatment.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=1;spage=37;epage=39;aulast=SadeghianBacterial infectioncutaneous leishmaniasisglucantime |
| spellingShingle | G Sadeghian H Ziaei L Shirani Bidabadi A Zolfaghari Baghbaderani Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection Indian Journal of Dermatology Bacterial infection cutaneous leishmaniasis glucantime |
| title | Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection |
| title_full | Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection |
| title_fullStr | Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection |
| title_full_unstemmed | Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection |
| title_short | Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection |
| title_sort | decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection |
| topic | Bacterial infection cutaneous leishmaniasis glucantime |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=1;spage=37;epage=39;aulast=Sadeghian |
| work_keys_str_mv | AT gsadeghian decreasedeffectofglucantimeincutaneousleishmaniasiscomplicatedwithsecondarybacterialinfection AT hziaei decreasedeffectofglucantimeincutaneousleishmaniasiscomplicatedwithsecondarybacterialinfection AT lshiranibidabadi decreasedeffectofglucantimeincutaneousleishmaniasiscomplicatedwithsecondarybacterialinfection AT azolfagharibaghbaderani decreasedeffectofglucantimeincutaneousleishmaniasiscomplicatedwithsecondarybacterialinfection |