Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV
The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies. Here, we discuss three current views—the so-called solid, fluid and plasticity models—which descri...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037019300935 |
| _version_ | 1819016110909947904 |
|---|---|
| author | Gonzalo Pérez-Mejías Alejandra Guerra-Castellano Antonio Díaz-Quintana Miguel A. De la Rosa Irene Díaz-Moreno |
| author_facet | Gonzalo Pérez-Mejías Alejandra Guerra-Castellano Antonio Díaz-Quintana Miguel A. De la Rosa Irene Díaz-Moreno |
| author_sort | Gonzalo Pérez-Mejías |
| collection | DOAJ |
| description | The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies. Here, we discuss three current views—the so-called solid, fluid and plasticity models—which describe the organization of the main membrane-embedded mitochondrial protein complexes and the key elements that regulate and/or facilitate supercomplex assembly. The soluble electron carrier cytochrome c has recently emerged as an essential factor in the assembly and function of respiratory supercomplexes. In fact, a ‘restricted diffusion pathway’ mechanism for electron transfer between complexes III and IV has been proposed based on the secondary, distal binding sites for cytochrome c at its two membrane partners recently discovered. This channeling pathway facilitates the surfing of cytochrome c on both respiratory complexes, thereby tuning the efficiency of oxidative phosphorylation and diminishing the production of reactive oxygen species. The well-documented post-translational modifications of cytochrome c could further contribute to the rapid adjustment of electron flow in response to changing cellular conditions. Keywords: Cytochrome c, Mitochondria, Phosphorylation, Reactive oxygen species, Respiratory supercomplexes |
| first_indexed | 2024-12-21T02:42:26Z |
| format | Article |
| id | doaj.art-beaaa2adce6c44149d79042251732d72 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-21T02:42:26Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-beaaa2adce6c44149d79042251732d722022-12-21T19:18:40ZengElsevierComputational and Structural Biotechnology Journal2001-03702019-01-0117654660Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IVGonzalo Pérez-Mejías0Alejandra Guerra-Castellano1Antonio Díaz-Quintana2Miguel A. De la Rosa3Irene Díaz-Moreno4Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja), Universidad de Sevilla – Consejo Superior de Investigaciones Científicas (CSIC), Avda. Américo Vespucio 49, Sevilla 41092, SpainInstituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja), Universidad de Sevilla – Consejo Superior de Investigaciones Científicas (CSIC), Avda. Américo Vespucio 49, Sevilla 41092, SpainInstituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja), Universidad de Sevilla – Consejo Superior de Investigaciones Científicas (CSIC), Avda. Américo Vespucio 49, Sevilla 41092, SpainInstituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja), Universidad de Sevilla – Consejo Superior de Investigaciones Científicas (CSIC), Avda. Américo Vespucio 49, Sevilla 41092, SpainCorresponding author.; Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja), Universidad de Sevilla – Consejo Superior de Investigaciones Científicas (CSIC), Avda. Américo Vespucio 49, Sevilla 41092, SpainThe proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies. Here, we discuss three current views—the so-called solid, fluid and plasticity models—which describe the organization of the main membrane-embedded mitochondrial protein complexes and the key elements that regulate and/or facilitate supercomplex assembly. The soluble electron carrier cytochrome c has recently emerged as an essential factor in the assembly and function of respiratory supercomplexes. In fact, a ‘restricted diffusion pathway’ mechanism for electron transfer between complexes III and IV has been proposed based on the secondary, distal binding sites for cytochrome c at its two membrane partners recently discovered. This channeling pathway facilitates the surfing of cytochrome c on both respiratory complexes, thereby tuning the efficiency of oxidative phosphorylation and diminishing the production of reactive oxygen species. The well-documented post-translational modifications of cytochrome c could further contribute to the rapid adjustment of electron flow in response to changing cellular conditions. Keywords: Cytochrome c, Mitochondria, Phosphorylation, Reactive oxygen species, Respiratory supercomplexeshttp://www.sciencedirect.com/science/article/pii/S2001037019300935 |
| spellingShingle | Gonzalo Pérez-Mejías Alejandra Guerra-Castellano Antonio Díaz-Quintana Miguel A. De la Rosa Irene Díaz-Moreno Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV Computational and Structural Biotechnology Journal |
| title | Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV |
| title_full | Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV |
| title_fullStr | Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV |
| title_full_unstemmed | Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV |
| title_short | Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV |
| title_sort | cytochrome c surfing off of the mitochondrial membrane on the tops of complexes iii and iv |
| url | http://www.sciencedirect.com/science/article/pii/S2001037019300935 |
| work_keys_str_mv | AT gonzaloperezmejias cytochromecsurfingoffofthemitochondrialmembraneonthetopsofcomplexesiiiandiv AT alejandraguerracastellano cytochromecsurfingoffofthemitochondrialmembraneonthetopsofcomplexesiiiandiv AT antoniodiazquintana cytochromecsurfingoffofthemitochondrialmembraneonthetopsofcomplexesiiiandiv AT migueladelarosa cytochromecsurfingoffofthemitochondrialmembraneonthetopsofcomplexesiiiandiv AT irenediazmoreno cytochromecsurfingoffofthemitochondrialmembraneonthetopsofcomplexesiiiandiv |