Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis
Hyperhidrosis is a condition characterized by excessive sweating that affects at least 5% of the world’s population. It is normally associated with unpleasant body odour which requires continuous maintenance throughout life. Antiperspirants and deodorants are the first-line treatments for hyperhidro...
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/2297-8739/10/6/324 |
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| author | Nurliyana A. M. Sidek Khairana Husain Fhataheya Buang Mazlina Mohd Said |
| author_facet | Nurliyana A. M. Sidek Khairana Husain Fhataheya Buang Mazlina Mohd Said |
| author_sort | Nurliyana A. M. Sidek |
| collection | DOAJ |
| description | Hyperhidrosis is a condition characterized by excessive sweating that affects at least 5% of the world’s population. It is normally associated with unpleasant body odour which requires continuous maintenance throughout life. Antiperspirants and deodorants are the first-line treatments for hyperhidrosis. However, association of this class of product with the risk of other diseases has increased the search for an effective antiperspirant from natural sources. This study aimed to investigate the antibacterial and antiperspirant activities of <i>Curcuma xanthorrhiza</i> Roxb. Using an in vitro microbial assay against specific bacteria responsible for body odour and rat foot pad analysis. Quality control of the fractionated extract was conducted using reversed-phase HPLC based on two active markers: xanthorrhiza and curcumin. Toxicity tests were conducted based on the OECD guidelines (50–2000 mg/kg). Inhibition zone, MIC, and MBC values of the hexane fraction of <i>C. xanthorrhiza</i> showed equivalent antibacterial activity to positive control (<i>p</i> > 0.05). No swelling, redness, or rashes were observed at the injection area throughout the study. Treatment with 40, 80, and 160 mg/kg of the extract significantly decreased the sweat excretion up to 79.34% (<i>p</i> < 0.05) after 15 min compared to negative control. Histopathology analysis showed the reduced size of the secretory units in plantar sweat glands post treatment compared to negative control. In conclusion, the hexane fraction of <i>C. xanthorrhiza</i> is able to reduce sweat excretion in a rat model and inhibit the growth of bacteria causing body odour. |
| first_indexed | 2024-03-11T01:56:21Z |
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| last_indexed | 2024-03-11T01:56:21Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-beab797bdb1c4626bad739feb8df7ad32023-11-18T12:35:57ZengMDPI AGSeparations2297-87392023-05-0110632410.3390/separations10060324Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for HyperhidrosisNurliyana A. M. Sidek0Khairana Husain1Fhataheya Buang2Mazlina Mohd Said3Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Drug and Herbal Development, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Drug and Herbal Development, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Drug and Herbal Development, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaHyperhidrosis is a condition characterized by excessive sweating that affects at least 5% of the world’s population. It is normally associated with unpleasant body odour which requires continuous maintenance throughout life. Antiperspirants and deodorants are the first-line treatments for hyperhidrosis. However, association of this class of product with the risk of other diseases has increased the search for an effective antiperspirant from natural sources. This study aimed to investigate the antibacterial and antiperspirant activities of <i>Curcuma xanthorrhiza</i> Roxb. Using an in vitro microbial assay against specific bacteria responsible for body odour and rat foot pad analysis. Quality control of the fractionated extract was conducted using reversed-phase HPLC based on two active markers: xanthorrhiza and curcumin. Toxicity tests were conducted based on the OECD guidelines (50–2000 mg/kg). Inhibition zone, MIC, and MBC values of the hexane fraction of <i>C. xanthorrhiza</i> showed equivalent antibacterial activity to positive control (<i>p</i> > 0.05). No swelling, redness, or rashes were observed at the injection area throughout the study. Treatment with 40, 80, and 160 mg/kg of the extract significantly decreased the sweat excretion up to 79.34% (<i>p</i> < 0.05) after 15 min compared to negative control. Histopathology analysis showed the reduced size of the secretory units in plantar sweat glands post treatment compared to negative control. In conclusion, the hexane fraction of <i>C. xanthorrhiza</i> is able to reduce sweat excretion in a rat model and inhibit the growth of bacteria causing body odour.https://www.mdpi.com/2297-8739/10/6/324<i>Curcuma xanthorrhiza</i>antimicrobialantiperspirantsweatingherbal medicinesbody odour |
| spellingShingle | Nurliyana A. M. Sidek Khairana Husain Fhataheya Buang Mazlina Mohd Said Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis Separations <i>Curcuma xanthorrhiza</i> antimicrobial antiperspirant sweating herbal medicines body odour |
| title | Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis |
| title_full | Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis |
| title_fullStr | Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis |
| title_full_unstemmed | Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis |
| title_short | Antiperspirant and Antibacterial Activities of <i>Curcuma xanthorrhiza</i> Extract as a Potential Alternative Treatment for Hyperhidrosis |
| title_sort | antiperspirant and antibacterial activities of i curcuma xanthorrhiza i extract as a potential alternative treatment for hyperhidrosis |
| topic | <i>Curcuma xanthorrhiza</i> antimicrobial antiperspirant sweating herbal medicines body odour |
| url | https://www.mdpi.com/2297-8739/10/6/324 |
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