Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy
Abstract Background High Programmed death ligand 1 (PD-L1) expression are thought to be necessary to PD-1/PD-L1 axis blockades in many tumors. The aim of the study was to explore the variation of PD-L1 expression after neoadjuvant chemotherapy (NAC) in cervical squamous cell carcinoma (SCC) and its...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-020-00977-1 |
| _version_ | 1818517147920367616 |
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| author | Yun Liang Minghua Yu Caiyun Zhou Xiaojun Zhu |
| author_facet | Yun Liang Minghua Yu Caiyun Zhou Xiaojun Zhu |
| author_sort | Yun Liang |
| collection | DOAJ |
| description | Abstract Background High Programmed death ligand 1 (PD-L1) expression are thought to be necessary to PD-1/PD-L1 axis blockades in many tumors. The aim of the study was to explore the variation of PD-L1 expression after neoadjuvant chemotherapy (NAC) in cervical squamous cell carcinoma (SCC) and its clinical implications. Methods A total of 142 paired SCC specimens before and after platinum-based NAC were obtained from cervical cancer patients. The expression of PD-L1 and CD3+, CD4+, CD8+ tumor infiltrating lymphocytes (TILs) was detected by immunohistochemistry and the association between TILs, chemotherapy response, clinical outcome and PD-L1 expression was evaluated. Results The fraction of patients with high PD-L1 expression was significantly increased from 32.4 to 46.5% after NAC (χ2 = 5.897, p = 0.015), while the increase of CD3+, CD4+, CD8+ TILs was not significant. High PD-L1 expression was not associated with CD3+, CD4+, CD8+ TILs before NAC, however CD8+ TILs infiltration was positively associated with high PD-L1 expression after NAC (r = 0.205, p = 0.014). The decreased PD-L1 expression was more observed in patients with clinical response to NAC (χ2 = 6.890, p = 0.009). A longer DFS was seen in patients with decreased PD-L1 expression than those with elevated or stable PD-L1 expression (p = 0.048, 95% CI: 0.091–0.987), while the difference was not significant in multivariate analysis (p = 0.113, 95% CI: 0.108–1.266). Conclusions Cisplatin based chemotherapy can increase PD-L1 expression in cervical cancer. The increased PD-L1 expression and a lymphocyte predominant microenvironment after chemotherapy provide a rational for use of PD-1/PD-L1 axis-inhibitor in the neoadjuvant setting. |
| first_indexed | 2024-12-11T00:52:16Z |
| format | Article |
| id | doaj.art-beabfec8bc314498aff05aee7c12167e |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-11T00:52:16Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-beabfec8bc314498aff05aee7c12167e2022-12-22T01:26:35ZengBMCDiagnostic Pathology1746-15962020-06-011511810.1186/s13000-020-00977-1Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapyYun Liang0Minghua Yu1Caiyun Zhou2Xiaojun Zhu3Department of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang UniversityDepartment of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang UniversityDepartment of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang UniversityDepartment of Gynaecology and Obstetrics, the Affiliated Women’s Hospital, School of Medicine, Zhejiang UniversityAbstract Background High Programmed death ligand 1 (PD-L1) expression are thought to be necessary to PD-1/PD-L1 axis blockades in many tumors. The aim of the study was to explore the variation of PD-L1 expression after neoadjuvant chemotherapy (NAC) in cervical squamous cell carcinoma (SCC) and its clinical implications. Methods A total of 142 paired SCC specimens before and after platinum-based NAC were obtained from cervical cancer patients. The expression of PD-L1 and CD3+, CD4+, CD8+ tumor infiltrating lymphocytes (TILs) was detected by immunohistochemistry and the association between TILs, chemotherapy response, clinical outcome and PD-L1 expression was evaluated. Results The fraction of patients with high PD-L1 expression was significantly increased from 32.4 to 46.5% after NAC (χ2 = 5.897, p = 0.015), while the increase of CD3+, CD4+, CD8+ TILs was not significant. High PD-L1 expression was not associated with CD3+, CD4+, CD8+ TILs before NAC, however CD8+ TILs infiltration was positively associated with high PD-L1 expression after NAC (r = 0.205, p = 0.014). The decreased PD-L1 expression was more observed in patients with clinical response to NAC (χ2 = 6.890, p = 0.009). A longer DFS was seen in patients with decreased PD-L1 expression than those with elevated or stable PD-L1 expression (p = 0.048, 95% CI: 0.091–0.987), while the difference was not significant in multivariate analysis (p = 0.113, 95% CI: 0.108–1.266). Conclusions Cisplatin based chemotherapy can increase PD-L1 expression in cervical cancer. The increased PD-L1 expression and a lymphocyte predominant microenvironment after chemotherapy provide a rational for use of PD-1/PD-L1 axis-inhibitor in the neoadjuvant setting.http://link.springer.com/article/10.1186/s13000-020-00977-1Squamous cell carcinomaCervixTumor infiltrating lymphocytesPD-L1Neoadjuvant chemotherapy |
| spellingShingle | Yun Liang Minghua Yu Caiyun Zhou Xiaojun Zhu Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy Diagnostic Pathology Squamous cell carcinoma Cervix Tumor infiltrating lymphocytes PD-L1 Neoadjuvant chemotherapy |
| title | Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy |
| title_full | Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy |
| title_fullStr | Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy |
| title_full_unstemmed | Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy |
| title_short | Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy |
| title_sort | variation of pd l1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy |
| topic | Squamous cell carcinoma Cervix Tumor infiltrating lymphocytes PD-L1 Neoadjuvant chemotherapy |
| url | http://link.springer.com/article/10.1186/s13000-020-00977-1 |
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