Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy
Several options to treat hospitalized severe COVID-19 patients have been suggested. The study aimed to describe survival in patients treated with convalescent COVID plasma (CCP) and to identify in-hospital mortality predictors. This prospective cohort study examined data from 112 severe COVID-19 pat...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295964/?tool=EBI |
| _version_ | 1817969002834558976 |
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| author | Naomi Rahimi-Levene Jonathan Shapira Irma Tzur Eli Shiloah Victoria Peer Ella Levin Marina Izak Eilat Shinar Tomer Ziv-Baran Miriam Weinberger Oren Zimhony Jacob Chen Yasmin Maor |
| author_facet | Naomi Rahimi-Levene Jonathan Shapira Irma Tzur Eli Shiloah Victoria Peer Ella Levin Marina Izak Eilat Shinar Tomer Ziv-Baran Miriam Weinberger Oren Zimhony Jacob Chen Yasmin Maor |
| author_sort | Naomi Rahimi-Levene |
| collection | DOAJ |
| description | Several options to treat hospitalized severe COVID-19 patients have been suggested. The study aimed to describe survival in patients treated with convalescent COVID plasma (CCP) and to identify in-hospital mortality predictors. This prospective cohort study examined data from 112 severe COVID-19 patients hospitalized in the Corona Departments in an acute care hospital who received two units of CCP (at least one of them high-titer). Demographic and medical data was retrieved from the patients’ electronic health records (EHR). Possible predictors for in-hospital mortality were analyzed in a univariate analysis and those found to be clinically significant were further analyzed in a multivariable analysis. Median age was 67 years (IQR 55–74) and 66 (58.9%) of them were males. Of them, 20 (17.9%) died in hospital. On multivariable analysis diabetes mellitus (p = 0.004, OR 91.54), mechanical ventilation (p = 0.001, OR 59.07) and lower albumin levels at treatment (p = 0.027, OR 0.74) were significantly associated with increased in-hospital mortality. In our study, in-hospital mortality in patients receiving CCP is similar to that reported for the general population, however certain variables mentioned above were associated with increased in-hospital mortality. In the literature, these variables were also associated with a worse outcome in patients with COVID-19 who did not receive CCP. As evidence points toward a benefit from CCP treatment in immunocompromised patients, we believe the above risk factors can further define COVID-19 patients at increased risk for mortality, enabling the selection of candidates for early treatment in an outpatient setting if possible. |
| first_indexed | 2024-04-13T20:15:48Z |
| format | Article |
| id | doaj.art-bead6392495c4853ba6f71113b20536d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T20:15:48Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bead6392495c4853ba6f71113b20536d2022-12-22T02:31:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177Predictors of mortality in COVID-19 patients treated with convalescent plasma therapyNaomi Rahimi-LeveneJonathan ShapiraIrma TzurEli ShiloahVictoria PeerElla LevinMarina IzakEilat ShinarTomer Ziv-BaranMiriam WeinbergerOren ZimhonyJacob ChenYasmin MaorSeveral options to treat hospitalized severe COVID-19 patients have been suggested. The study aimed to describe survival in patients treated with convalescent COVID plasma (CCP) and to identify in-hospital mortality predictors. This prospective cohort study examined data from 112 severe COVID-19 patients hospitalized in the Corona Departments in an acute care hospital who received two units of CCP (at least one of them high-titer). Demographic and medical data was retrieved from the patients’ electronic health records (EHR). Possible predictors for in-hospital mortality were analyzed in a univariate analysis and those found to be clinically significant were further analyzed in a multivariable analysis. Median age was 67 years (IQR 55–74) and 66 (58.9%) of them were males. Of them, 20 (17.9%) died in hospital. On multivariable analysis diabetes mellitus (p = 0.004, OR 91.54), mechanical ventilation (p = 0.001, OR 59.07) and lower albumin levels at treatment (p = 0.027, OR 0.74) were significantly associated with increased in-hospital mortality. In our study, in-hospital mortality in patients receiving CCP is similar to that reported for the general population, however certain variables mentioned above were associated with increased in-hospital mortality. In the literature, these variables were also associated with a worse outcome in patients with COVID-19 who did not receive CCP. As evidence points toward a benefit from CCP treatment in immunocompromised patients, we believe the above risk factors can further define COVID-19 patients at increased risk for mortality, enabling the selection of candidates for early treatment in an outpatient setting if possible.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295964/?tool=EBI |
| spellingShingle | Naomi Rahimi-Levene Jonathan Shapira Irma Tzur Eli Shiloah Victoria Peer Ella Levin Marina Izak Eilat Shinar Tomer Ziv-Baran Miriam Weinberger Oren Zimhony Jacob Chen Yasmin Maor Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy PLoS ONE |
| title | Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy |
| title_full | Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy |
| title_fullStr | Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy |
| title_full_unstemmed | Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy |
| title_short | Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy |
| title_sort | predictors of mortality in covid 19 patients treated with convalescent plasma therapy |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295964/?tool=EBI |
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