LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway

LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway

Abstract Background Epithelial-to-mesenchymal transition (EMT) is a critical event contributing to more aggressive phenotypes in cancer cells. EMT is frequently activated in radiation-targeted cells during the course of radiotherapy, which often endows cancers with acquired radioresistance. However,...

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Bibliographic Details
Main Authors: Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai, Ping-Kun Zhou
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Translational Medicine
Subjects:
LPAR5
ERK
Radioresistance
EMT
Radiotherapy
Online Access:https://doi.org/10.1186/s12967-022-03673-4

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