Dietary aldose reductase inhibitors and prevention of diabetic complications
Prolonged exposure to hyperglycemia can lead to the development of complications such as cataracts, retinopathy, neuropathy, and nephropathy. Several mechanisms are supposed to be involved in this process such as increased aldose reductase (AR)-related polyol pathway, increased formation of advanced...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2021;volume=14;issue=2;spage=194;epage=199;aulast=Anjum |
| _version_ | 1819104622292238336 |
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| author | Ameena Anjum Janamolla Sreeja Yarlagadda Swapna Rajesh Bolleddu Sama Venkatesh |
| author_facet | Ameena Anjum Janamolla Sreeja Yarlagadda Swapna Rajesh Bolleddu Sama Venkatesh |
| author_sort | Ameena Anjum |
| collection | DOAJ |
| description | Prolonged exposure to hyperglycemia can lead to the development of complications such as cataracts, retinopathy, neuropathy, and nephropathy. Several mechanisms are supposed to be involved in this process such as increased aldose reductase (AR)-related polyol pathway, increased formation of advanced glycation end products, and excessive oxidation stress in the body. AR is the principal enzyme of the polyol pathway in the development of secondary complications of diabetes, and its inhibition provides a significant strategy to prevent these complications. Synthetic aldose reductase inhibitors (ARIs) have been developed, but they suffer drawbacks and safety issues demanding research on natural sources for potential ARIs. Many dietary substances and phytochemicals were reported as being good source of ARIs including Spinacia oleracea, Ocimum sanctum, Foeniculum vulgare, Momordica charantia, Cinamomum zeylencium, and Cuminum cyminum. This review was undertaken to provide an insight into the use of dietary ARIs for prevention, delay, or management of the secondary complications and to serve as a guide for further research for their optimum and effective use and also to create awareness among the diabetics. |
| first_indexed | 2024-12-22T02:09:17Z |
| format | Article |
| id | doaj.art-beaf384473024568ba84a4d0d0e3e03c |
| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-12-22T02:09:17Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-beaf384473024568ba84a4d0d0e3e03c2022-12-21T18:42:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222021-01-0114219419910.4103/kleuhsj.kleuhsj_105_19Dietary aldose reductase inhibitors and prevention of diabetic complicationsAmeena AnjumJanamolla SreejaYarlagadda SwapnaRajesh BolledduSama VenkateshProlonged exposure to hyperglycemia can lead to the development of complications such as cataracts, retinopathy, neuropathy, and nephropathy. Several mechanisms are supposed to be involved in this process such as increased aldose reductase (AR)-related polyol pathway, increased formation of advanced glycation end products, and excessive oxidation stress in the body. AR is the principal enzyme of the polyol pathway in the development of secondary complications of diabetes, and its inhibition provides a significant strategy to prevent these complications. Synthetic aldose reductase inhibitors (ARIs) have been developed, but they suffer drawbacks and safety issues demanding research on natural sources for potential ARIs. Many dietary substances and phytochemicals were reported as being good source of ARIs including Spinacia oleracea, Ocimum sanctum, Foeniculum vulgare, Momordica charantia, Cinamomum zeylencium, and Cuminum cyminum. This review was undertaken to provide an insight into the use of dietary ARIs for prevention, delay, or management of the secondary complications and to serve as a guide for further research for their optimum and effective use and also to create awareness among the diabetics.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2021;volume=14;issue=2;spage=194;epage=199;aulast=Anjumaldose reductase inhibitorsdiabetesdiabetic complicationsphytochemicals |
| spellingShingle | Ameena Anjum Janamolla Sreeja Yarlagadda Swapna Rajesh Bolleddu Sama Venkatesh Dietary aldose reductase inhibitors and prevention of diabetic complications Indian Journal of Health Sciences and Biomedical Research KLEU aldose reductase inhibitors diabetes diabetic complications phytochemicals |
| title | Dietary aldose reductase inhibitors and prevention of diabetic complications |
| title_full | Dietary aldose reductase inhibitors and prevention of diabetic complications |
| title_fullStr | Dietary aldose reductase inhibitors and prevention of diabetic complications |
| title_full_unstemmed | Dietary aldose reductase inhibitors and prevention of diabetic complications |
| title_short | Dietary aldose reductase inhibitors and prevention of diabetic complications |
| title_sort | dietary aldose reductase inhibitors and prevention of diabetic complications |
| topic | aldose reductase inhibitors diabetes diabetic complications phytochemicals |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2021;volume=14;issue=2;spage=194;epage=199;aulast=Anjum |
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