The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression.
The Polycomb group (PcG) proteins have been implicated in epigenetic transcriptional repression in development, stem cell maintenance and in cancer. The chromodomain protein Polycomb (Pc) is a key member of the PcG. Pc binds to the histone mark, trimethylated histone 3 lysine 27 (H3K27me3), to initi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5493352?pdf=render |
| _version_ | 1811343651440164864 |
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| author | Pranabananda Dutta Willis X Li |
| author_facet | Pranabananda Dutta Willis X Li |
| author_sort | Pranabananda Dutta |
| collection | DOAJ |
| description | The Polycomb group (PcG) proteins have been implicated in epigenetic transcriptional repression in development, stem cell maintenance and in cancer. The chromodomain protein Polycomb (Pc) is a key member of the PcG. Pc binds to the histone mark, trimethylated histone 3 lysine 27 (H3K27me3), to initiate transcriptional repression. How PcG proteins are recruited to target loci is not fully understood. Here we show that the Drosophila SERTA domain protein Taranis (Tara) is involved in transcriptional regulation of Pc target genes. Embryos lacking Tara exhibit a partial homeotic transformation of cuticular the segments, a phenotype associated with the loss of Pc function. Moreover, Drosophila embryos homozygous for a tara hypomorphic allele also misexpress engrailed, a Pc-regulated gene, and this phenotype is associated with the loss of Pc binding to the cis response element in the engrailed enhancer. In relation to that, Pc recruitment is reduced on the salivary gland polytene chromosomes and specifically at the engrailed locus. These results suggest that Tara might be required for positioning Pc to a subset of its target genes. |
| first_indexed | 2024-04-13T19:33:43Z |
| format | Article |
| id | doaj.art-beb12a773dcc4b5aa66b81db71c2f9c7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T19:33:43Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-beb12a773dcc4b5aa66b81db71c2f9c72022-12-22T02:33:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e018002610.1371/journal.pone.0180026The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression.Pranabananda DuttaWillis X LiThe Polycomb group (PcG) proteins have been implicated in epigenetic transcriptional repression in development, stem cell maintenance and in cancer. The chromodomain protein Polycomb (Pc) is a key member of the PcG. Pc binds to the histone mark, trimethylated histone 3 lysine 27 (H3K27me3), to initiate transcriptional repression. How PcG proteins are recruited to target loci is not fully understood. Here we show that the Drosophila SERTA domain protein Taranis (Tara) is involved in transcriptional regulation of Pc target genes. Embryos lacking Tara exhibit a partial homeotic transformation of cuticular the segments, a phenotype associated with the loss of Pc function. Moreover, Drosophila embryos homozygous for a tara hypomorphic allele also misexpress engrailed, a Pc-regulated gene, and this phenotype is associated with the loss of Pc binding to the cis response element in the engrailed enhancer. In relation to that, Pc recruitment is reduced on the salivary gland polytene chromosomes and specifically at the engrailed locus. These results suggest that Tara might be required for positioning Pc to a subset of its target genes.http://europepmc.org/articles/PMC5493352?pdf=render |
| spellingShingle | Pranabananda Dutta Willis X Li The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. PLoS ONE |
| title | The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. |
| title_full | The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. |
| title_fullStr | The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. |
| title_full_unstemmed | The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. |
| title_short | The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression. |
| title_sort | sertad protein taranis plays a role in polycomb mediated gene repression |
| url | http://europepmc.org/articles/PMC5493352?pdf=render |
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