Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments
Background: Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/10/2771 |
| _version_ | 1797552505649889280 |
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| author | Takamichi Morikawa Takahiko Shibahara Takeshi Nomura Akira Katakura Masayuki Takano |
| author_facet | Takamichi Morikawa Takahiko Shibahara Takeshi Nomura Akira Katakura Masayuki Takano |
| author_sort | Takamichi Morikawa |
| collection | DOAJ |
| description | Background: Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations can be repeated using optical instruments. The purpose of this study was to clarify the usefulness of fluorescence visualization in oral cancer screening. Methods: A total of 502 patients, who were examined using fluorescence visualization with optical instruments in our hospitals between 2014 and 2019, were enrolled in this study. The final diagnosis was performed by pathological examination. Fluorescence visualization was analyzed using subjective and objective evaluations. Results: Subjective evaluations for detecting oral cancer offered 96.8% sensitivity and 48.4% specificity. Regarding the objective evaluations, sensitivity and specificity were 43.7% and 84.6% for mean green value, 55.2% and 67.0% for median green value, 82.0% and 44.2% for coefficient of variation of value, 59.6% and 45.3% for skewness, and 85.1% and 75.8% for value ratio. For the sub-analysis of oral cancer, all factors on objective and subjective evaluation showed no significant difference. Conclusions: Fluorescence visualization with subjective and objective evaluation is useful for oral cancer screening. |
| first_indexed | 2024-03-10T16:01:04Z |
| format | Article |
| id | doaj.art-beb16e568549455bb334d54b0e86a5d5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T16:01:04Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-beb16e568549455bb334d54b0e86a5d52023-11-20T15:15:58ZengMDPI AGCancers2072-66942020-09-011210277110.3390/cancers12102771Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical InstrumentsTakamichi Morikawa0Takahiko Shibahara1Takeshi Nomura2Akira Katakura3Masayuki Takano4Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo 102-8159, JapanDepartment of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo 102-8159, JapanOral Cancer Center, Tokyo Dental College, Chiba 272-8513; JapanOral Cancer Center, Tokyo Dental College, Chiba 272-8513; JapanDepartment of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo 102-8159, JapanBackground: Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations can be repeated using optical instruments. The purpose of this study was to clarify the usefulness of fluorescence visualization in oral cancer screening. Methods: A total of 502 patients, who were examined using fluorescence visualization with optical instruments in our hospitals between 2014 and 2019, were enrolled in this study. The final diagnosis was performed by pathological examination. Fluorescence visualization was analyzed using subjective and objective evaluations. Results: Subjective evaluations for detecting oral cancer offered 96.8% sensitivity and 48.4% specificity. Regarding the objective evaluations, sensitivity and specificity were 43.7% and 84.6% for mean green value, 55.2% and 67.0% for median green value, 82.0% and 44.2% for coefficient of variation of value, 59.6% and 45.3% for skewness, and 85.1% and 75.8% for value ratio. For the sub-analysis of oral cancer, all factors on objective and subjective evaluation showed no significant difference. Conclusions: Fluorescence visualization with subjective and objective evaluation is useful for oral cancer screening.https://www.mdpi.com/2072-6694/12/10/2771oral canceroral squamous cell carcinomafluorescence visualization lossoral potentially malignant disordersoral cancer screeningoptical Instrument |
| spellingShingle | Takamichi Morikawa Takahiko Shibahara Takeshi Nomura Akira Katakura Masayuki Takano Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments Cancers oral cancer oral squamous cell carcinoma fluorescence visualization loss oral potentially malignant disorders oral cancer screening optical Instrument |
| title | Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments |
| title_full | Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments |
| title_fullStr | Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments |
| title_full_unstemmed | Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments |
| title_short | Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments |
| title_sort | non invasive early detection of oral cancers using fluorescence visualization with optical instruments |
| topic | oral cancer oral squamous cell carcinoma fluorescence visualization loss oral potentially malignant disorders oral cancer screening optical Instrument |
| url | https://www.mdpi.com/2072-6694/12/10/2771 |
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