The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial
This study aimed to evaluate the efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> (<i>L. bulgaricus</i>) in improving body weight, obesity-related outcomes, and lipid profiles of overweight people. Thirty-six overweight participants were randoml...
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MDPI AG
2024-02-01
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| Online Access: | https://www.mdpi.com/2218-1989/14/2/129 |
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| author | Pei-Yi Chu Ying-Chun Yu Yi-Cheng Pan Yun-Hao Dai Juan-Cheng Yang Kuo-Chin Huang Yang-Chang Wu |
| author_facet | Pei-Yi Chu Ying-Chun Yu Yi-Cheng Pan Yun-Hao Dai Juan-Cheng Yang Kuo-Chin Huang Yang-Chang Wu |
| author_sort | Pei-Yi Chu |
| collection | DOAJ |
| description | This study aimed to evaluate the efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> (<i>L. bulgaricus</i>) in improving body weight, obesity-related outcomes, and lipid profiles of overweight people. Thirty-six overweight participants were randomly assigned to either a probiotic or a placebo group. A placebo powder or <i>L. bulgaricus</i> powder (containing 1 × 10<sup>8</sup> colony-forming unit (CFU) of the probiotic) was administered daily for 12 weeks. Body composition was determined, and blood tests were performed before and after the intervention. <i>L. bulgaricus</i> supplementation under the present condition did not affect the body weight, fat percentage, or body mass index (BMI) of the participants, while it resulted in a notable decrease in blood triglyceride (TG) levels, which corresponded to a lowering of the TG proportion in the composition of large VLDL (L–XXL sized fractions) and HDL (M and L fractions) in the probiotic-treated group. These results suggest that <i>L. bulgaricus</i> supplementation under the current conditions may not be helpful for losing weight, but it has the potential to decrease blood TG levels by modulating TG accumulation in or transport by VLDL/HDL in obese patients. <i>L. bulgaricus</i> supplements may have health-promoting properties in preventing TG-related diseases in overweight people. |
| first_indexed | 2024-03-07T22:22:09Z |
| format | Article |
| id | doaj.art-beb304a4bd6d438c95198cab863ec1fe |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-07T22:22:09Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-beb304a4bd6d438c95198cab863ec1fe2024-02-23T15:27:08ZengMDPI AGMetabolites2218-19892024-02-0114212910.3390/metabo14020129The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot TrialPei-Yi Chu0Ying-Chun Yu1Yi-Cheng Pan2Yun-Hao Dai3Juan-Cheng Yang4Kuo-Chin Huang5Yang-Chang Wu6Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404327, TaiwanDepartment of Medical Research, Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404327, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404327, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404327, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404327, TaiwanSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404328, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404327, TaiwanThis study aimed to evaluate the efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> (<i>L. bulgaricus</i>) in improving body weight, obesity-related outcomes, and lipid profiles of overweight people. Thirty-six overweight participants were randomly assigned to either a probiotic or a placebo group. A placebo powder or <i>L. bulgaricus</i> powder (containing 1 × 10<sup>8</sup> colony-forming unit (CFU) of the probiotic) was administered daily for 12 weeks. Body composition was determined, and blood tests were performed before and after the intervention. <i>L. bulgaricus</i> supplementation under the present condition did not affect the body weight, fat percentage, or body mass index (BMI) of the participants, while it resulted in a notable decrease in blood triglyceride (TG) levels, which corresponded to a lowering of the TG proportion in the composition of large VLDL (L–XXL sized fractions) and HDL (M and L fractions) in the probiotic-treated group. These results suggest that <i>L. bulgaricus</i> supplementation under the current conditions may not be helpful for losing weight, but it has the potential to decrease blood TG levels by modulating TG accumulation in or transport by VLDL/HDL in obese patients. <i>L. bulgaricus</i> supplements may have health-promoting properties in preventing TG-related diseases in overweight people.https://www.mdpi.com/2218-1989/14/2/129<i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i>body weighttriglyceridelipoproteinobesity |
| spellingShingle | Pei-Yi Chu Ying-Chun Yu Yi-Cheng Pan Yun-Hao Dai Juan-Cheng Yang Kuo-Chin Huang Yang-Chang Wu The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial Metabolites <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> body weight triglyceride lipoprotein obesity |
| title | The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial |
| title_full | The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial |
| title_fullStr | The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial |
| title_full_unstemmed | The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial |
| title_short | The Efficacy of <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial |
| title_sort | efficacy of i lactobacillus delbrueckii i ssp i bulgaricus i supplementation in managing body weight and blood lipids of people with overweight a randomized pilot trial |
| topic | <i>Lactobacillus delbrueckii</i> ssp. <i>bulgaricus</i> body weight triglyceride lipoprotein obesity |
| url | https://www.mdpi.com/2218-1989/14/2/129 |
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