A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

We report herein a simple and efficient two-step synthetic approach to new 2-trichloromethylquinazolines possessing a variously substituted sulfonamide group at position 4 used to prepare new quinazolines with antiparasitic properties. Thus, an original series of 20 derivatives was synthesized, whic...

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Bibliographic Details
Main Authors: Nadine Azas, Sylvain Rault, Pascal Rathelot, Sébastien Hutter, Aurélien Dumètre, Charline Kieffer, Anita Cohen, Pierre Verhaeghe, Nicolas Primas, Patrice Vanelle
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Molecules
Subjects:
quinazoline
trichloromethyl group
sulfonamide
microwaves
antiplasmodial activity
Online Access:http://www.mdpi.com/1420-3049/17/7/8105

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