Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?
Abstract There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. To further explore these mechanisms, we measured the superior sagittal sinus (SSS)...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Fluids and Barriers of the CNS |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12987-017-0066-1 |
| _version_ | 1818975148733104128 |
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| author | Grant A. Bateman Jeannette Lechner-Scott Ross Copping Christopher Moeskops Swee Leong Yap |
| author_facet | Grant A. Bateman Jeannette Lechner-Scott Ross Copping Christopher Moeskops Swee Leong Yap |
| author_sort | Grant A. Bateman |
| collection | DOAJ |
| description | Abstract There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. To further explore these mechanisms, we measured the superior sagittal sinus (SSS) cross-sectional area 3 cm above the torcular using T2 images in 20 MS, 10 spontaneous intracranial hypotension (SIH), 21 hydrocephalus and 20 idiopathic intracranial hypertension (IIH) patients and compared with 20 matched controls. The SSS area was reduced by 25% in hydrocephalus (p = 0.0008), increased by 22% (p = 0.037) in SIH and unchanged in IIH compared to matched controls. In MS there was a 16% increase in SSS area (p = 0.01).The findings suggest that changes in SSS cross-sectional are common between MS and SIH patients, while in hydrocephalus and IIH these are different. |
| first_indexed | 2024-12-20T15:51:21Z |
| format | Article |
| id | doaj.art-beb3d6b3f8234435b07af78f994a3c87 |
| institution | Directory Open Access Journal |
| issn | 2045-8118 |
| language | English |
| last_indexed | 2024-12-20T15:51:21Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj.art-beb3d6b3f8234435b07af78f994a3c872022-12-21T19:34:40ZengBMCFluids and Barriers of the CNS2045-81182017-07-011411510.1186/s12987-017-0066-1Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?Grant A. Bateman0Jeannette Lechner-Scott1Ross Copping2Christopher Moeskops3Swee Leong Yap4Department of Medical Imaging, John Hunter HospitalNewcastle University Faculty of Health, Callaghan Campus NewcastleDepartment of Medical Imaging, John Hunter HospitalDepartment of Medical Imaging, John Hunter HospitalDepartment of Medical Imaging, John Hunter HospitalAbstract There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. To further explore these mechanisms, we measured the superior sagittal sinus (SSS) cross-sectional area 3 cm above the torcular using T2 images in 20 MS, 10 spontaneous intracranial hypotension (SIH), 21 hydrocephalus and 20 idiopathic intracranial hypertension (IIH) patients and compared with 20 matched controls. The SSS area was reduced by 25% in hydrocephalus (p = 0.0008), increased by 22% (p = 0.037) in SIH and unchanged in IIH compared to matched controls. In MS there was a 16% increase in SSS area (p = 0.01).The findings suggest that changes in SSS cross-sectional are common between MS and SIH patients, while in hydrocephalus and IIH these are different.http://link.springer.com/article/10.1186/s12987-017-0066-1Multiple sclerosisHydrocephalusIdiopathic intracranial hypertensionSpontaneous intracranial hypotension |
| spellingShingle | Grant A. Bateman Jeannette Lechner-Scott Ross Copping Christopher Moeskops Swee Leong Yap Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? Fluids and Barriers of the CNS Multiple sclerosis Hydrocephalus Idiopathic intracranial hypertension Spontaneous intracranial hypotension |
| title | Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? |
| title_full | Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? |
| title_fullStr | Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? |
| title_full_unstemmed | Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? |
| title_short | Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? |
| title_sort | comparison of the sagittal sinus cross sectional area between patients with multiple sclerosis hydrocephalus intracranial hypertension and spontaneous intracranial hypotension a surrogate marker of venous transmural pressure |
| topic | Multiple sclerosis Hydrocephalus Idiopathic intracranial hypertension Spontaneous intracranial hypotension |
| url | http://link.springer.com/article/10.1186/s12987-017-0066-1 |
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