Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes
Background: Intraoperative hypothermia is an integral part of cardiopulmonary bypass (CPB), and a precise degree of hypothermia may improve the early clinical outcomes of cardiac surgery. Presently, there is no agreement on an accurate, advantageous temperature range for routine use in CPB. To addre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/9/5/151 |
| _version_ | 1797498965384495104 |
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| author | Adnan Haider Irfan Azmatullah Khwaja Abdul Basit Qureshi Imran Khan Khalid Abdul Majeed Muhammad Shahbaz Yousaf Hafsa Zaneb Abdul Rehman Imtiaz Rabbani Sajid Khan Tahir Habib Rehman |
| author_facet | Adnan Haider Irfan Azmatullah Khwaja Abdul Basit Qureshi Imran Khan Khalid Abdul Majeed Muhammad Shahbaz Yousaf Hafsa Zaneb Abdul Rehman Imtiaz Rabbani Sajid Khan Tahir Habib Rehman |
| author_sort | Adnan Haider |
| collection | DOAJ |
| description | Background: Intraoperative hypothermia is an integral part of cardiopulmonary bypass (CPB), and a precise degree of hypothermia may improve the early clinical outcomes of cardiac surgery. Presently, there is no agreement on an accurate, advantageous temperature range for routine use in CPB. To address this issue, we conducted a retrospective observational study to compare the effects of different hypothermic temperature ranges on primary (inotropic support, blood loss, and platelet count) and secondary (ventilation support and in-hospital stay) outcomes in patients undergoing elective cardiac surgery. Methods: Data were retrieved from the medical database of the Cardiovascular Surgery Department, King Edward Medical University, Lahore-Pakistan (a tertiary care hospital), dating from February 2015 to December 2017. Patients were divided into mild (34 °C to 36 °C), intermediate (31 °C to 33 °C), or moderate (28 °C to 30 °C) hypothermic groups. Results: Out of 275 patients, 245 (89.09%) fit the inclusion criteria. The cohort with mild hypothermic CPB temperatures presented better clinical outcomes in terms of requiring less inotropic support, less blood loss, fewer blood transfusions, improved platelet counts, shorter in-hospital stays, and required less ventilation support, when compared with other hypothermic groups. Conclusions: Mild hypothermic CPB (34 °C to 36 °C) may produce better clinical outcomes for cardiac surgery and improve the quality of health of cardiac patients. |
| first_indexed | 2024-03-10T03:40:49Z |
| format | Article |
| id | doaj.art-beb72a01fd5741809565a55c6a51bf79 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T03:40:49Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-beb72a01fd5741809565a55c6a51bf792023-11-23T11:32:52ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-05-019515110.3390/jcdd9050151Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical OutcomesAdnan Haider0Irfan Azmatullah Khwaja1Abdul Basit Qureshi2Imran Khan3Khalid Abdul Majeed4Muhammad Shahbaz Yousaf5Hafsa Zaneb6Abdul Rehman7Imtiaz Rabbani8Sajid Khan Tahir9Habib Rehman10Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Cardiovascular Surgery, King Edward Medical University, Lahore 54000, PakistanDepartment of Surgery, Services Institute of Medical Sciences, Lahore 54810, PakistanDepartment of Cardiolothoracic and Vascular Surgery, Almana General Hospital, AL Khobar 31952, Saudi ArabiaDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanBackground: Intraoperative hypothermia is an integral part of cardiopulmonary bypass (CPB), and a precise degree of hypothermia may improve the early clinical outcomes of cardiac surgery. Presently, there is no agreement on an accurate, advantageous temperature range for routine use in CPB. To address this issue, we conducted a retrospective observational study to compare the effects of different hypothermic temperature ranges on primary (inotropic support, blood loss, and platelet count) and secondary (ventilation support and in-hospital stay) outcomes in patients undergoing elective cardiac surgery. Methods: Data were retrieved from the medical database of the Cardiovascular Surgery Department, King Edward Medical University, Lahore-Pakistan (a tertiary care hospital), dating from February 2015 to December 2017. Patients were divided into mild (34 °C to 36 °C), intermediate (31 °C to 33 °C), or moderate (28 °C to 30 °C) hypothermic groups. Results: Out of 275 patients, 245 (89.09%) fit the inclusion criteria. The cohort with mild hypothermic CPB temperatures presented better clinical outcomes in terms of requiring less inotropic support, less blood loss, fewer blood transfusions, improved platelet counts, shorter in-hospital stays, and required less ventilation support, when compared with other hypothermic groups. Conclusions: Mild hypothermic CPB (34 °C to 36 °C) may produce better clinical outcomes for cardiac surgery and improve the quality of health of cardiac patients.https://www.mdpi.com/2308-3425/9/5/151cardiac surgeryinotropic supportin-hospital stayblood lossthrombocytopenia |
| spellingShingle | Adnan Haider Irfan Azmatullah Khwaja Abdul Basit Qureshi Imran Khan Khalid Abdul Majeed Muhammad Shahbaz Yousaf Hafsa Zaneb Abdul Rehman Imtiaz Rabbani Sajid Khan Tahir Habib Rehman Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes Journal of Cardiovascular Development and Disease cardiac surgery inotropic support in-hospital stay blood loss thrombocytopenia |
| title | Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes |
| title_full | Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes |
| title_fullStr | Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes |
| title_full_unstemmed | Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes |
| title_short | Effectiveness of Mild to Moderate Hypothermic Cardiopulmonary Bypass on Early Clinical Outcomes |
| title_sort | effectiveness of mild to moderate hypothermic cardiopulmonary bypass on early clinical outcomes |
| topic | cardiac surgery inotropic support in-hospital stay blood loss thrombocytopenia |
| url | https://www.mdpi.com/2308-3425/9/5/151 |
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