Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart

C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as a...

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Main Author: Akihiro Yasoda
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/11/6/911
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author Akihiro Yasoda
author_facet Akihiro Yasoda
author_sort Akihiro Yasoda
collection DOAJ
description C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as an autocrine/paracrine regulator with broad expression in the body. Because of its low expression levels compared to ANP and BNP, early studies failed to show its existence and role in the heart. However, recent studies have revealed the physiological and pathophysiological importance of CNP in the heart; in concert with the distribution of its specific natriuretic peptide receptor-B (NPR-B), CNP has come to be regarded as the major heart-protective natriuretic peptide in the failed heart. NPR-B generates intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) upon CNP binding, followed by various molecular effects including the activation of cGMP-dependent protein kinases, which generates diverse cytoprotective actions in cardiomyocytes, as well as in cardiac fibroblasts. CNP exerts negative inotropic and positive lusitropic responses in both normal and failing heart models. Furthermore, osteocrin, the intrinsic and specific ligand for the clearance receptor for natriuretic peptides, can augment the effects of CNP and may supply a novel therapeutic strategy for cardiac protection.
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spelling doaj.art-beb8c749ff1240f18e24fa072810836b2023-11-23T15:40:22ZengMDPI AGBiology2079-77372022-06-0111691110.3390/biology11060911Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the HeartAkihiro Yasoda0National Hospital Organization Kyoto Medical Center, 1-1, Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, JapanC-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as an autocrine/paracrine regulator with broad expression in the body. Because of its low expression levels compared to ANP and BNP, early studies failed to show its existence and role in the heart. However, recent studies have revealed the physiological and pathophysiological importance of CNP in the heart; in concert with the distribution of its specific natriuretic peptide receptor-B (NPR-B), CNP has come to be regarded as the major heart-protective natriuretic peptide in the failed heart. NPR-B generates intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) upon CNP binding, followed by various molecular effects including the activation of cGMP-dependent protein kinases, which generates diverse cytoprotective actions in cardiomyocytes, as well as in cardiac fibroblasts. CNP exerts negative inotropic and positive lusitropic responses in both normal and failing heart models. Furthermore, osteocrin, the intrinsic and specific ligand for the clearance receptor for natriuretic peptides, can augment the effects of CNP and may supply a novel therapeutic strategy for cardiac protection.https://www.mdpi.com/2079-7737/11/6/911CNPNPR-Bosteocrin
spellingShingle Akihiro Yasoda
Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
Biology
CNP
NPR-B
osteocrin
title Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
title_full Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
title_fullStr Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
title_full_unstemmed Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
title_short Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
title_sort physiological and pathophysiological effects of c type natriuretic peptide on the heart
topic CNP
NPR-B
osteocrin
url https://www.mdpi.com/2079-7737/11/6/911
work_keys_str_mv AT akihiroyasoda physiologicalandpathophysiologicaleffectsofctypenatriureticpeptideontheheart