C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.

Bibliographic Details
Main Authors: Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer
Format: Article
Language:English
Published: Nature Portfolio 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14556-x
Description
Summary:In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
ISSN:2041-1723

Similar Items