miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene

miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene

Abstract Background Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a crucial role in the metastatic cascade through degradation of the basement membrane and surrounding stroma. Co...

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Bibliographic Details
Main Authors: Yongwen Li, Hongbing Zhang, Hao Gong, Yin Yuan, Ying Li, Cong Wang, Weiting Li, Zihe Zhang, Minghui Liu, Hongyu Liu, Jun Chen
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lung cancer
miRNA-182
Cortactin
Metastasis
Invadopodia
Online Access:http://link.springer.com/article/10.1186/s13046-018-0824-1

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