Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans
Abstract An animal’s ability to sense odors declines during aging, and its olfactory drive is tuned by internal states such as satiety. However, whether internal states modulate an age-dependent decline in odor sensation is unknown. To address this issue, we utilized the nematode Caenorhabditis eleg...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52272-4 |
| _version_ | 1797266865956847616 |
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| author | Nadia Suryawinata Rikuou Yokosawa Ke Hui Cassandra Tan Alison Lok Lai Ryusei Sone Ikue Mori Kentaro Noma |
| author_facet | Nadia Suryawinata Rikuou Yokosawa Ke Hui Cassandra Tan Alison Lok Lai Ryusei Sone Ikue Mori Kentaro Noma |
| author_sort | Nadia Suryawinata |
| collection | DOAJ |
| description | Abstract An animal’s ability to sense odors declines during aging, and its olfactory drive is tuned by internal states such as satiety. However, whether internal states modulate an age-dependent decline in odor sensation is unknown. To address this issue, we utilized the nematode Caenorhabditis elegans and compared their chemotaxis abilities toward attractive odorants when aged under different dietary conditions. Feeding with the standard laboratory diet, Escherichia coli attenuated the chemotaxis ability toward diacetyl, isoamyl alcohol, and benzaldehyde when aged. On the other hand, feeding with either the lactic acid bacteria Lactobacillus reuteri or food deprivation selectively maintained the chemotaxis ability toward diacetyl. Our results suggest that ingestion of E. coli causes age-dependent chemotaxis decline. The changes in the chemotaxis behavior are attributed to the different expressions of diacetyl receptor odr-10, and the chemotaxis behavior of aged animals under food deprivation is shown to be dependent on daf-16. Our study demonstrates the molecular mechanism of how diet shapes the trajectory of age-dependent decline in chemosensory behaviors. |
| first_indexed | 2024-04-25T01:07:29Z |
| format | Article |
| id | doaj.art-bebcb7025deb4321bd346a0a493d18a1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-25T01:07:29Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bebcb7025deb4321bd346a0a493d18a12024-03-10T12:10:20ZengNature PortfolioScientific Reports2045-23222024-03-0114111410.1038/s41598-024-52272-4Dietary E. coli promotes age-dependent chemotaxis decline in C. elegansNadia Suryawinata0Rikuou Yokosawa1Ke Hui Cassandra Tan2Alison Lok Lai3Ryusei Sone4Ikue Mori5Kentaro Noma6Group of Nutritional Neuroscience, Graduate School of Science, Neuroscience Institute, Nagoya UniversityGroup of Nutritional Neuroscience, Graduate School of Science, Neuroscience Institute, Nagoya UniversityGroup of Nutritional Neuroscience, Graduate School of Science, Neuroscience Institute, Nagoya UniversityGroup of Nutritional Neuroscience, Graduate School of Science, Neuroscience Institute, Nagoya UniversityGroup of Nutritional Neuroscience, Graduate School of Science, Neuroscience Institute, Nagoya UniversityGroup of Molecular Neurobiology, Graduate School of Science, Neuroscience Institute, Nagoya UniversityGroup of Nutritional Neuroscience, Graduate School of Science, Neuroscience Institute, Nagoya UniversityAbstract An animal’s ability to sense odors declines during aging, and its olfactory drive is tuned by internal states such as satiety. However, whether internal states modulate an age-dependent decline in odor sensation is unknown. To address this issue, we utilized the nematode Caenorhabditis elegans and compared their chemotaxis abilities toward attractive odorants when aged under different dietary conditions. Feeding with the standard laboratory diet, Escherichia coli attenuated the chemotaxis ability toward diacetyl, isoamyl alcohol, and benzaldehyde when aged. On the other hand, feeding with either the lactic acid bacteria Lactobacillus reuteri or food deprivation selectively maintained the chemotaxis ability toward diacetyl. Our results suggest that ingestion of E. coli causes age-dependent chemotaxis decline. The changes in the chemotaxis behavior are attributed to the different expressions of diacetyl receptor odr-10, and the chemotaxis behavior of aged animals under food deprivation is shown to be dependent on daf-16. Our study demonstrates the molecular mechanism of how diet shapes the trajectory of age-dependent decline in chemosensory behaviors.https://doi.org/10.1038/s41598-024-52272-4 |
| spellingShingle | Nadia Suryawinata Rikuou Yokosawa Ke Hui Cassandra Tan Alison Lok Lai Ryusei Sone Ikue Mori Kentaro Noma Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans Scientific Reports |
| title | Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans |
| title_full | Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans |
| title_fullStr | Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans |
| title_full_unstemmed | Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans |
| title_short | Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans |
| title_sort | dietary e coli promotes age dependent chemotaxis decline in c elegans |
| url | https://doi.org/10.1038/s41598-024-52272-4 |
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