Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation
Although autophagy is a process that has been studied for several years its link with antigen presentation and T cell immunity has only recently emerged. Autophagy, which means self-eating, is important to maintain cell homeostasis and refers to a collection of mechanisms that delivers intracellular...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00459/full |
| _version_ | 1819228874200842240 |
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| author | Fernanda V. Duraes Jennifer eNiven Jennifer eNiven Juan eDubrot Stephanie eHugues Monique eGannagé Monique eGannagé |
| author_facet | Fernanda V. Duraes Jennifer eNiven Jennifer eNiven Juan eDubrot Stephanie eHugues Monique eGannagé Monique eGannagé |
| author_sort | Fernanda V. Duraes |
| collection | DOAJ |
| description | Although autophagy is a process that has been studied for several years its link with antigen presentation and T cell immunity has only recently emerged. Autophagy, which means self-eating, is important to maintain cell homeostasis and refers to a collection of mechanisms that delivers intracellular material for degradation into lysosomes. Among them, macroautophagy pathway has many implications in different biological processes, including innate and adaptive immunity. In particular, macroautophagy can provide a substantial source of intracellular antigens for loading onto MHC class II molecules, using the alternative MHC class II pathway. Through autophagosomes, endogenous self-antigens, as well as antigens derived from intracellular pathogens can be delivered to MHC class II compartment and presented to CD4+ T cells. The pathway will therefore impact both peripheral T cell tolerance and the pathogen specific immune response. This review will describe the contribution of autophagy to intracellular presentation of endogenous self- or pathogen derived-antigens via MHC class II and its consequences on CD4+ T cell responses. |
| first_indexed | 2024-12-23T11:04:12Z |
| format | Article |
| id | doaj.art-bec011ac482444f696e3ed9bef9391a5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T11:04:12Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bec011ac482444f696e3ed9bef9391a52022-12-21T17:49:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-09-01610.3389/fimmu.2015.00459154638Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentationFernanda V. Duraes0Jennifer eNiven1Jennifer eNiven2Juan eDubrot3Stephanie eHugues4Monique eGannagé5Monique eGannagé6University of geneva-School of medicine-University of geneva-School of medicine-University Hospital,University of geneva-School of medicine-University of geneva-School of medicine-University of geneva-School of medicine-University Hospital,Although autophagy is a process that has been studied for several years its link with antigen presentation and T cell immunity has only recently emerged. Autophagy, which means self-eating, is important to maintain cell homeostasis and refers to a collection of mechanisms that delivers intracellular material for degradation into lysosomes. Among them, macroautophagy pathway has many implications in different biological processes, including innate and adaptive immunity. In particular, macroautophagy can provide a substantial source of intracellular antigens for loading onto MHC class II molecules, using the alternative MHC class II pathway. Through autophagosomes, endogenous self-antigens, as well as antigens derived from intracellular pathogens can be delivered to MHC class II compartment and presented to CD4+ T cells. The pathway will therefore impact both peripheral T cell tolerance and the pathogen specific immune response. This review will describe the contribution of autophagy to intracellular presentation of endogenous self- or pathogen derived-antigens via MHC class II and its consequences on CD4+ T cell responses.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00459/fullCD4-Positive T-Lymphocytestolerance mechanismsMHC class IIMacroautophagyAntigen Presentation/Processing |
| spellingShingle | Fernanda V. Duraes Jennifer eNiven Jennifer eNiven Juan eDubrot Stephanie eHugues Monique eGannagé Monique eGannagé Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation Frontiers in Immunology CD4-Positive T-Lymphocytes tolerance mechanisms MHC class II Macroautophagy Antigen Presentation/Processing |
| title | Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation |
| title_full | Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation |
| title_fullStr | Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation |
| title_full_unstemmed | Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation |
| title_short | Macroautophagy in endogenous processing of self and pathogen derived antigens for MHC class II presentation |
| title_sort | macroautophagy in endogenous processing of self and pathogen derived antigens for mhc class ii presentation |
| topic | CD4-Positive T-Lymphocytes tolerance mechanisms MHC class II Macroautophagy Antigen Presentation/Processing |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00459/full |
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