Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
Yun-jing Hou,1 Xin-xin Yang,1 Rui-qi Liu,2 Di Zhao,1 Chen-xu Guo,1 An-chao Zhu,1 Mei-na Wen,1 Zhao Liu,3 Guo-fan Qu,4 Hong-xue Meng1 1Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Radiation Oncology, Sun Yat-Sen Unive...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/pathological-mechanism-of-photodynamic-therapy-and-photothermal-therap-peer-reviewed-article-IJN |
| _version_ | 1818994179104047104 |
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| author | Hou Y Yang X Liu R Zhao D Guo C Zhu A Wen M Liu Z Qu G Meng H |
| author_facet | Hou Y Yang X Liu R Zhao D Guo C Zhu A Wen M Liu Z Qu G Meng H |
| author_sort | Hou Y |
| collection | DOAJ |
| description | Yun-jing Hou,1 Xin-xin Yang,1 Rui-qi Liu,2 Di Zhao,1 Chen-xu Guo,1 An-chao Zhu,1 Mei-na Wen,1 Zhao Liu,3 Guo-fan Qu,4 Hong-xue Meng1 1Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Hospital, Guangzhou, People’s Republic of China; 3Department of Ultrasound, Harbin Medical University, Harbin, People’s Republic of China; 4Department of Orthopedics, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of ChinaCorrespondence: Hong-xue Meng Department of PathologyHarbin Medical University Cancer Hospital, 150 Haping Road, Harbin, People’s Republic of ChinaTel +86-451-85718261Email menghongxue15@163.comAbstract: The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.Keywords: pathological mechanism, nanoparticles, photothermal therapy, PTT, photodynamic therapy, PDT |
| first_indexed | 2024-12-20T20:53:50Z |
| format | Article |
| id | doaj.art-bec0c9aaf1f6470ea97e7b366d507383 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-20T20:53:50Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-bec0c9aaf1f6470ea97e7b366d5073832022-12-21T19:26:53ZengDove Medical PressInternational Journal of Nanomedicine1178-20132020-09-01Volume 156827683857055Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on NanoparticlesHou YYang XLiu RZhao DGuo CZhu AWen MLiu ZQu GMeng HYun-jing Hou,1 Xin-xin Yang,1 Rui-qi Liu,2 Di Zhao,1 Chen-xu Guo,1 An-chao Zhu,1 Mei-na Wen,1 Zhao Liu,3 Guo-fan Qu,4 Hong-xue Meng1 1Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Hospital, Guangzhou, People’s Republic of China; 3Department of Ultrasound, Harbin Medical University, Harbin, People’s Republic of China; 4Department of Orthopedics, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of ChinaCorrespondence: Hong-xue Meng Department of PathologyHarbin Medical University Cancer Hospital, 150 Haping Road, Harbin, People’s Republic of ChinaTel +86-451-85718261Email menghongxue15@163.comAbstract: The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.Keywords: pathological mechanism, nanoparticles, photothermal therapy, PTT, photodynamic therapy, PDThttps://www.dovepress.com/pathological-mechanism-of-photodynamic-therapy-and-photothermal-therap-peer-reviewed-article-IJNpathological mechanismnanoparticlesphotothermal therapy(ptt)，photodynamic therapy(pdt) |
| spellingShingle | Hou Y Yang X Liu R Zhao D Guo C Zhu A Wen M Liu Z Qu G Meng H Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles International Journal of Nanomedicine pathological mechanism nanoparticles photothermal therapy(ptt)，photodynamic therapy(pdt) |
| title | Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles |
| title_full | Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles |
| title_fullStr | Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles |
| title_full_unstemmed | Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles |
| title_short | Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles |
| title_sort | pathological mechanism of photodynamic therapy and photothermal therapy based on nanoparticles |
| topic | pathological mechanism nanoparticles photothermal therapy(ptt)，photodynamic therapy(pdt) |
| url | https://www.dovepress.com/pathological-mechanism-of-photodynamic-therapy-and-photothermal-therap-peer-reviewed-article-IJN |
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