Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer
Abstract Cervical cancer is one of the most common and important gynecological cancers, which has a global concern with an increasing number of patients and mortality rates. Today, most women in the world who suffer from cervical cancer are developing advanced stages of the disease. Smoking and even...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00789-x |
| _version_ | 1797967814519160832 |
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| author | Parinaz Zivarpour Elhameh Nikkhah Parisa Maleki Dana Zatollah Asemi Jamal Hallajzadeh |
| author_facet | Parinaz Zivarpour Elhameh Nikkhah Parisa Maleki Dana Zatollah Asemi Jamal Hallajzadeh |
| author_sort | Parinaz Zivarpour |
| collection | DOAJ |
| description | Abstract Cervical cancer is one of the most common and important gynecological cancers, which has a global concern with an increasing number of patients and mortality rates. Today, most women in the world who suffer from cervical cancer are developing advanced stages of the disease. Smoking and even exposure to secondhand smoke, infections caused by the human papillomavirus, immune system dysfunction and high-risk individual-social behaviors are among the most important predisposing factors for this type of cancer. In addition, papilloma virus infection plays a more prominent role in cervical cancer. Surgery, chemotherapy or radical hysterectomy, and radiotherapy are effective treatments for this condition, the side effects of these methods endanger a person’s quality of life and cause other problems in other parts of the body. Studies show that herbal medicines, including taxol, camptothecin and combretastatins, have been shown to be effective in treating cervical cancer. Ginger (Zingiber officinale, Zingiberaceae) is one of the plants with valuable compounds such as gingerols, paradols and shogoals, which is a rich source of antioxidants, anti-cancer and anti-inflammatory agents. Numerous studies have reported the therapeutic effects of this plant through various pathways in cervical cancer. In this article, we look at the signaling mechanisms and pathways in which ginger is used to treat cervical cancer. |
| first_indexed | 2024-04-11T02:37:06Z |
| format | Article |
| id | doaj.art-bec24f9604b74a0e9a7f6c8880423228 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:37:06Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-bec24f9604b74a0e9a7f6c88804232282023-01-02T20:03:26ZengBMCJournal of Ovarian Research1757-22152021-03-0114111310.1186/s13048-021-00789-xMolecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancerParinaz Zivarpour0Elhameh Nikkhah1Parisa Maleki Dana2Zatollah Asemi3Jamal Hallajzadeh4Department of Biological sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-RashidMedicinal Plants Research Cent Maragheh University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesDepartment of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical SciencesAbstract Cervical cancer is one of the most common and important gynecological cancers, which has a global concern with an increasing number of patients and mortality rates. Today, most women in the world who suffer from cervical cancer are developing advanced stages of the disease. Smoking and even exposure to secondhand smoke, infections caused by the human papillomavirus, immune system dysfunction and high-risk individual-social behaviors are among the most important predisposing factors for this type of cancer. In addition, papilloma virus infection plays a more prominent role in cervical cancer. Surgery, chemotherapy or radical hysterectomy, and radiotherapy are effective treatments for this condition, the side effects of these methods endanger a person’s quality of life and cause other problems in other parts of the body. Studies show that herbal medicines, including taxol, camptothecin and combretastatins, have been shown to be effective in treating cervical cancer. Ginger (Zingiber officinale, Zingiberaceae) is one of the plants with valuable compounds such as gingerols, paradols and shogoals, which is a rich source of antioxidants, anti-cancer and anti-inflammatory agents. Numerous studies have reported the therapeutic effects of this plant through various pathways in cervical cancer. In this article, we look at the signaling mechanisms and pathways in which ginger is used to treat cervical cancer.https://doi.org/10.1186/s13048-021-00789-xCervical cancerGynecological cancersHuman papillomavirusGinger |
| spellingShingle | Parinaz Zivarpour Elhameh Nikkhah Parisa Maleki Dana Zatollah Asemi Jamal Hallajzadeh Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer Journal of Ovarian Research Cervical cancer Gynecological cancers Human papillomavirus Ginger |
| title | Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer |
| title_full | Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer |
| title_fullStr | Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer |
| title_full_unstemmed | Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer |
| title_short | Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer |
| title_sort | molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer |
| topic | Cervical cancer Gynecological cancers Human papillomavirus Ginger |
| url | https://doi.org/10.1186/s13048-021-00789-x |
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