Hypoxia-inducible factors, mTOR, and astrin constitute an integrative regulatory network in colon cancer cells

Hypoxia-inducible factors, mTOR, and astrin constitute an integrative regulatory network in colon cancer cells

Astrin/SPAG5 is a mitotic spindle protein found to be overexpressed in several human cancers, functioning as an oncogene. The expression of Astrin has not been reported so far in colon cancer, nor has it been related to HIFs expression or action. Since mTOR, Astrin, and hypoxia-inducible factors (HI...

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Bibliographic Details
Main Authors:	Abril Saint-Martin, Marco Antonio Morquecho-León, Maria Cristina Castañeda-Patlán, Martha Robles-Flores
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Series:	Biochemistry and Biophysics Reports
Subjects:	Hypoxia-inducible factors mTOR regulation Astrin/SPAG5 HIF-1α HIF-2α Colon cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580822001364

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