Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms
Introduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2016-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320316655669 |
| _version_ | 1797283620414554112 |
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| author | Marcin Cwynar Jerzy Gąsowski Anna Głuszewska Jarosław Królczyk Henryk Bartoń Agnieszka Słowik Tomasz Grodzicki |
| author_facet | Marcin Cwynar Jerzy Gąsowski Anna Głuszewska Jarosław Królczyk Henryk Bartoń Agnieszka Słowik Tomasz Grodzicki |
| author_sort | Marcin Cwynar |
| collection | DOAJ |
| description | Introduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes (AIx P , AIx C1 , AIx C2 ), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms. Proximal (FE Li ) and distal (FDR Na ) sodium reabsorption measurements were performed using endogenous lithium clearance. Results: In men, we found interaction between FDR Na and AGTR2 G1675A polymorphism with respect to AIx C1 ( p INT =0.01), AIx C2 ( p INT =0.05) and AIx P ( p INT =0.006). Arterial stiffness increased with higher sodium reabsorption in the distal tubule, in the presence of AGTR2 G allele with the opposite tendency in A allele carriers. In the subgroup with FDR Na below median, as compared to those with FDR Na above median, the AIx C1 (139.6±3.8 vs 159.1±5.7%; p =0.009), AIx C2 (26.3±1.8 vs 33.3±1.7%; p =0.016) and AIx P (83.4±2.5 vs 96.5±2.6%; p <0.0001) were lower, in the G allele carrying men and GG homozygous women. Conclusions: The relation between sodium reabsorption in the distal tubule and the development of arterial stiffness depends on the AGTR2 G1675A polymorphism in blood pressure independent fashion. |
| first_indexed | 2024-03-07T17:34:24Z |
| format | Article |
| id | doaj.art-bec423a41e774635a3bf5076197e86c8 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:34:24Z |
| publishDate | 2016-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-bec423a41e774635a3bf5076197e86c82024-03-02T17:15:59ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762016-06-011710.1177/1470320316655669Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphismsMarcin Cwynar0Jerzy Gąsowski1Anna Głuszewska2Jarosław Królczyk3Henryk Bartoń4Agnieszka Słowik5Tomasz Grodzicki6Department of Internal Medicine and Gerontology, Jagiellonian University, PolandDepartment of Internal Medicine and Gerontology, Jagiellonian University, PolandDepartment of Internal Medicine and Gerontology, Jagiellonian University, PolandDepartment of Internal Medicine and Gerontology, Jagiellonian University, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University, PolandDepartment of Neurology, Jagiellonian University, PolandDepartment of Internal Medicine and Gerontology, Jagiellonian University, PolandIntroduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes (AIx P , AIx C1 , AIx C2 ), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms. Proximal (FE Li ) and distal (FDR Na ) sodium reabsorption measurements were performed using endogenous lithium clearance. Results: In men, we found interaction between FDR Na and AGTR2 G1675A polymorphism with respect to AIx C1 ( p INT =0.01), AIx C2 ( p INT =0.05) and AIx P ( p INT =0.006). Arterial stiffness increased with higher sodium reabsorption in the distal tubule, in the presence of AGTR2 G allele with the opposite tendency in A allele carriers. In the subgroup with FDR Na below median, as compared to those with FDR Na above median, the AIx C1 (139.6±3.8 vs 159.1±5.7%; p =0.009), AIx C2 (26.3±1.8 vs 33.3±1.7%; p =0.016) and AIx P (83.4±2.5 vs 96.5±2.6%; p <0.0001) were lower, in the G allele carrying men and GG homozygous women. Conclusions: The relation between sodium reabsorption in the distal tubule and the development of arterial stiffness depends on the AGTR2 G1675A polymorphism in blood pressure independent fashion.https://doi.org/10.1177/1470320316655669 |
| spellingShingle | Marcin Cwynar Jerzy Gąsowski Anna Głuszewska Jarosław Królczyk Henryk Bartoń Agnieszka Słowik Tomasz Grodzicki Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms Journal of the Renin-Angiotensin-Aldosterone System |
| title | Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms |
| title_full | Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms |
| title_fullStr | Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms |
| title_full_unstemmed | Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms |
| title_short | Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms |
| title_sort | blood pressure arterial stiffness and endogenous lithium clearance in relation to agtr1 and agtr2 gene polymorphisms |
| url | https://doi.org/10.1177/1470320316655669 |
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