PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity

PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity

Tissue-specific cardiolipin fatty acyl profiles are achieved by remodeling of de novo synthesized cardiolipin, and four remodeling enzymes have thus far been identified. We studied the enzyme phospholipase A and acyltransferase 1 (PLAAT1), and we report the discovery that it has phosphatidylcholine...

Full description

Bibliographic Details
Main Authors:	Ryan M. Bradley, Ashkan Hashemi, Juan J. Aristizabal-Henao, Ken D. Stark, Robin E. Duncan
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	International Journal of Molecular Sciences
Subjects:	cardiolipin monolysocardiolipin remodeling enzyme phospholipase A acyltransferase 1 (PLAAT1)
Online Access:	https://www.mdpi.com/1422-0067/23/12/6714

Similar Items

Acylation of monolysocardiolipin in rat heart
by: Brian J. Ma, et al.
Published: (1999-10-01)

PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
by: Xin Zhao, et al.
Published: (2022-09-01)

Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis
by: Fredoen Valianpour, et al.
Published: (2005-06-01)

Omega-3 and omega-6 fatty acid differentially impact cardiolipin remodeling in activated macrophage
by: Wan-Hsin Chang, et al.
Published: (2018-08-01)

Current Knowledge on the Role of Cardiolipin Remodeling in the Context of Lipid Oxidation and Barth Syndrome
by: Zhuqing Liang, et al.
Published: (2022-05-01)

ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease
by: Yiqun Hao, et al.
Published: (2024-01-01)

Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes
by: Naoki Shinohara, et al.
Published: (2011-11-01)

A patatin-like phospholipase is important for mitochondrial function in malaria parasites
by: Emma Pietsch, et al.
Published: (2023-12-01)

Impact of Phosphate Availability on Membrane Lipid Content of the Model Strains, Streptomyces lividans and Streptomyces coelicolor
by: Clara Lejeune, et al.
Published: (2021-02-01)

Cardiolipin Biosynthesis Genes Are Not Required for Salmonella enterica Serovar Typhimurium Pathogenesis in C57BL/6J Mice
by: Melina B. Cian, et al.
Published: (2022-06-01)

Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca<sup>2+</sup>-Independent Phospholipase A<sub>2</sub>γ in the Brain
by: Pavla Průchová, et al.
Published: (2022-01-01)

Phospholipase A/acyltransferase 4 is a prognostic biomarker and correlated with immune infiltrates in pancreatic cancer
by: Tian-Hao Li, et al.
Published: (2022-09-01)

Lipase-Catalyzed Preparation and Optimization of Structured Phosphatidylcholine Containing Nervonic Acid
by: Xun Ang, et al.
Published: (2024-03-01)

Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells
by: J. Matías Caviglia, et al.
Published: (2004-08-01)

Case report: Variability in clinical features as a potential pitfall for the diagnosis of Barth syndrome
by: Nicola Tovaglieri, et al.
Published: (2023-08-01)

Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria[S]
by: Sneha S. Prasad, et al.
Published: (2011-03-01)

Involvement of the γ Isoform of cPLA<sub>2</sub> in the Biosynthesis of Bioactive <i>N-</i>Acylethanolamines
by: Yiman Guo, et al.
Published: (2021-08-01)

Use of immobilized phospholipase A1-catalyzed acidolysis for the production of structured phosphatidylcholine with an elevated conjugated linoleic acid content
by: R. Baeza-Jiménez, et al.
Published: (2012-03-01)

Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase c of bacillus cereus/
by: Johansen, Terje, et al.

Polar Head Modified Phospholipids by Phospholipase D-Catalyzed Transformations of Natural Phosphatidylcholine for Targeted Applications: An Overview
by: Chiara Allegretti, et al.
Published: (2020-09-01)

Enhanced production of hydroxy fatty acids in Arabidopsis seed through modification of multiple gene expression
by: Mid-Eum Park, et al.
Published: (2022-06-01)

Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer
by: Seyedeh Tayebeh Ahmadpour, et al.
Published: (2020-10-01)

Cross-species complementation of bacterial- and eukaryotic-type cardiolipin synthases
by: Petra Gottier, et al.
Published: (2017-11-01)

Lipid droplets control mitogenic lipid mediator production in human cancer cells
by: Eva Jarc Jovičić, et al.
Published: (2023-10-01)

The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type
by: Toru Uyama, et al.
Published: (2009-04-01)

Identification of a novel splice site mutation in the SERAC1 gene responsible for the MEGDHEL syndrome
by: Sarah Snanoudj, et al.
Published: (2019-08-01)

Phenobarbital-induced alterations in phosphatidylcholine and triglyceride synthesis in hepatic endoplasmic reticulum
by: DAVID L. YOUNG, et al.
Published: (1971-01-01)

Decreasing cytosolic translation is beneficial to yeast and human Tafazzin-deficient cells
by: Maxence de Taffin de Tilques, et al.
Published: (2018-02-01)

Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells[S]
by: Philippe Pierre Robichaud, et al.
Published: (2013-10-01)

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice
by: Anil K. Agarwal, et al.
Published: (2016-04-01)

Catalytic properties of MGAT3, a putative triacylgycerol synthases⃞
by: Jingsong Cao, et al.
Published: (2007-03-01)

Advances in the role of lysophosphatidyl-choline acyltransferase 1 in tumors
by: CHEN Xue, LUO Tian, WEI Chaojun
Published: (2024-02-01)

Kaempferol Improves Cardiolipin and ATP in Hepatic Cells: A Cellular Model Perspective in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease
by: Akiko Sakurai, et al.
Published: (2024-02-01)

Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I
by: Kevin W. Huggins, et al.
Published: (1998-12-01)

PB1F2 from Influenza A Virus Regulates the Interaction between Cytochrome C and Cardiolipin
by: Yujuan Wang, et al.
Published: (2022-08-01)

In Search of the Holy Grail: Toward a Unified Hypothesis on Mitochondrial Dysfunction in Age-Related Diseases
by: Jun Zhang, et al.
Published: (2022-06-01)

Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation
by: Xueling Liu, et al.
Published: (2022-09-01)

Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion
by: Yifan Ge, et al.
Published: (2021-12-01)

The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence
by: Valeria Manganelli, et al.
Published: (2021-02-01)

Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2γ-deficient mice[S]
by: Emiko Yoda, et al.
Published: (2010-10-01)