Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study
Osteoporosis and sarcopenia are two chronic conditions, which widely affect older people and share common risk factors. We investigated the prevalence of low bone mineral density (BMD) and sarcopenia, including the overlap of both conditions (osteosarcopenia) in 572 older hospitalized patients (mean...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/3786 |
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| author | Maryam Pourhassan Bjoern Buehring Ulrik Stervbo Sven Rahmann Felix Mölder Sebastian Rütten Ulrike Trampisch Nina Babel Timm Henning Westhoff Rainer Wirth |
| author_facet | Maryam Pourhassan Bjoern Buehring Ulrik Stervbo Sven Rahmann Felix Mölder Sebastian Rütten Ulrike Trampisch Nina Babel Timm Henning Westhoff Rainer Wirth |
| author_sort | Maryam Pourhassan |
| collection | DOAJ |
| description | Osteoporosis and sarcopenia are two chronic conditions, which widely affect older people and share common risk factors. We investigated the prevalence of low bone mineral density (BMD) and sarcopenia, including the overlap of both conditions (osteosarcopenia) in 572 older hospitalized patients (mean age 75.1 ± 10.8 years, 78% women) with known or suspected osteoporosis in this prospective observational multicenter study. Sarcopenia was assessed according to the revised definition of the European Working Group on Sarcopenia in Older People (EWGSOP2). Low BMD was defined according to the World Health Organization (WHO) recommendations as a T-score < −1.0. Osteosarcopenia was diagnosed when both low BMD and sarcopenia were present. Low BMD was prevalent in 76% and the prevalence of sarcopenia was 9%, with 90% of the sarcopenic patients showing the overlap of osteosarcopenia (8% of the entire population). Conversely, only few patients with low BMD demonstrated sarcopenia (11%). Osteosarcopenic patients were older and frailer and had lower BMI, fat, and muscle mass, handgrip strength, and T-score compared to nonosteosarcopenic patients. We conclude that osteosarcopenia is extremely common in sarcopenic subjects. Considering the increased risk of falls in patients with sarcopenia, they should always be evaluated for osteoporosis. |
| first_indexed | 2024-03-10T05:12:10Z |
| format | Article |
| id | doaj.art-bec4ef7b30e549369bb397059e3a7573 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:12:10Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-bec4ef7b30e549369bb397059e3a75732023-11-23T00:45:55ZengMDPI AGNutrients2072-66432021-10-011311378610.3390/nu13113786Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys StudyMaryam Pourhassan0Bjoern Buehring1Ulrik Stervbo2Sven Rahmann3Felix Mölder4Sebastian Rütten5Ulrike Trampisch6Nina Babel7Timm Henning Westhoff8Rainer Wirth9Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-University Bochum, Hölkeskampring 40D, 44625 Herne, GermanyRheumazentrum Ruhrgebiet, Ruhr-University Bochum, 44649 Herne, GermanyCenter for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Marien Hospital Herne, Ruhr-University Bochum, 44625 Herne, GermanyAlgorithmic Bioinformatics, Center for Bioinformatics, Saarland University, 66041 Saarbrücken, GermanyAlgorithms for Reproducible Bioinformatics, Genome Informatics, Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyCenter for Orthopedics and Trauma Surgery, St. Anna Hospital, St. Elisabeth Gruppe, 44649 Herne, GermanyDepartment of Geriatric Medicine, Marien Hospital Herne, Ruhr-University Bochum, Hölkeskampring 40D, 44625 Herne, GermanyCenter for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Marien Hospital Herne, Ruhr-University Bochum, 44625 Herne, GermanyCenter for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Marien Hospital Herne, Ruhr-University Bochum, 44625 Herne, GermanyDepartment of Geriatric Medicine, Marien Hospital Herne, Ruhr-University Bochum, Hölkeskampring 40D, 44625 Herne, GermanyOsteoporosis and sarcopenia are two chronic conditions, which widely affect older people and share common risk factors. We investigated the prevalence of low bone mineral density (BMD) and sarcopenia, including the overlap of both conditions (osteosarcopenia) in 572 older hospitalized patients (mean age 75.1 ± 10.8 years, 78% women) with known or suspected osteoporosis in this prospective observational multicenter study. Sarcopenia was assessed according to the revised definition of the European Working Group on Sarcopenia in Older People (EWGSOP2). Low BMD was defined according to the World Health Organization (WHO) recommendations as a T-score < −1.0. Osteosarcopenia was diagnosed when both low BMD and sarcopenia were present. Low BMD was prevalent in 76% and the prevalence of sarcopenia was 9%, with 90% of the sarcopenic patients showing the overlap of osteosarcopenia (8% of the entire population). Conversely, only few patients with low BMD demonstrated sarcopenia (11%). Osteosarcopenic patients were older and frailer and had lower BMI, fat, and muscle mass, handgrip strength, and T-score compared to nonosteosarcopenic patients. We conclude that osteosarcopenia is extremely common in sarcopenic subjects. Considering the increased risk of falls in patients with sarcopenia, they should always be evaluated for osteoporosis.https://www.mdpi.com/2072-6643/13/11/3786osteopeniaosteoporosissarcopeniaosteosarcopeniabone mineral densitymuscle mass |
| spellingShingle | Maryam Pourhassan Bjoern Buehring Ulrik Stervbo Sven Rahmann Felix Mölder Sebastian Rütten Ulrike Trampisch Nina Babel Timm Henning Westhoff Rainer Wirth Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study Nutrients osteopenia osteoporosis sarcopenia osteosarcopenia bone mineral density muscle mass |
| title | Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study |
| title_full | Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study |
| title_fullStr | Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study |
| title_full_unstemmed | Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study |
| title_short | Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study |
| title_sort | osteosarcopenia an asymmetrical overlap of two connected syndromes data from the osteosys study |
| topic | osteopenia osteoporosis sarcopenia osteosarcopenia bone mineral density muscle mass |
| url | https://www.mdpi.com/2072-6643/13/11/3786 |
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