Contemporary synthesis of bioactive cyclobutane natural products
Many cyclobutane natural products have intriguing biological properties that arise from their fascinating chemical structures. Cyclobutane natural products feature a cyclobutane scaffold as the core or as a part of the spirocyclic or fused cyclic core. However, the highly functionalized nature and t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2023-02-01
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| Series: | Green Synthesis and Catalysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554922000370 |
| _version_ | 1827987810196389888 |
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| author | Chunngai Hui Zhuo Wang Yusheng Xie Junyang Liu |
| author_facet | Chunngai Hui Zhuo Wang Yusheng Xie Junyang Liu |
| author_sort | Chunngai Hui |
| collection | DOAJ |
| description | Many cyclobutane natural products have intriguing biological properties that arise from their fascinating chemical structures. Cyclobutane natural products feature a cyclobutane scaffold as the core or as a part of the spirocyclic or fused cyclic core. However, the highly functionalized nature and the inherent stereochemistry of these cyclobutane natural products, which are associated with their biological activities, pose tremendous challenges to their preparation. In this perspective, we present contemporary advancements in synthetic methods and/or strategies en route to the bioactive cyclobutane natural products. We begin by describing the representative bioactive cyclobutane natural products and then focus on illustrative examples of their syntheses reported from 2018 to 2021. These advances will enable efficient syntheses of cyclobutanes of structural and biological importance. |
| first_indexed | 2024-04-09T23:53:54Z |
| format | Article |
| id | doaj.art-bec509596afb4242997b79e089088190 |
| institution | Directory Open Access Journal |
| issn | 2666-5549 |
| language | English |
| last_indexed | 2024-04-09T23:53:54Z |
| publishDate | 2023-02-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Green Synthesis and Catalysis |
| spelling | doaj.art-bec509596afb4242997b79e0890881902023-03-17T04:34:43ZengKeAi Communications Co. Ltd.Green Synthesis and Catalysis2666-55492023-02-014116Contemporary synthesis of bioactive cyclobutane natural productsChunngai Hui0Zhuo Wang1Yusheng Xie2Junyang Liu3Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund 44227, Germany; Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Dortmund 44221, Germany; Corresponding author. Max Planck Institute of Molecular Physiology, Department of Chemical Biology, 44227 Dortmund, Germany.Southern University of Science and Technology, School of Medicine, Shenzhen 518005, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China; Corresponding author.School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China; Corresponding author. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China.Many cyclobutane natural products have intriguing biological properties that arise from their fascinating chemical structures. Cyclobutane natural products feature a cyclobutane scaffold as the core or as a part of the spirocyclic or fused cyclic core. However, the highly functionalized nature and the inherent stereochemistry of these cyclobutane natural products, which are associated with their biological activities, pose tremendous challenges to their preparation. In this perspective, we present contemporary advancements in synthetic methods and/or strategies en route to the bioactive cyclobutane natural products. We begin by describing the representative bioactive cyclobutane natural products and then focus on illustrative examples of their syntheses reported from 2018 to 2021. These advances will enable efficient syntheses of cyclobutanes of structural and biological importance.http://www.sciencedirect.com/science/article/pii/S2666554922000370CyclobutaneNatural productsBioactiveSynthetic methodologyChemical synthesis |
| spellingShingle | Chunngai Hui Zhuo Wang Yusheng Xie Junyang Liu Contemporary synthesis of bioactive cyclobutane natural products Green Synthesis and Catalysis Cyclobutane Natural products Bioactive Synthetic methodology Chemical synthesis |
| title | Contemporary synthesis of bioactive cyclobutane natural products |
| title_full | Contemporary synthesis of bioactive cyclobutane natural products |
| title_fullStr | Contemporary synthesis of bioactive cyclobutane natural products |
| title_full_unstemmed | Contemporary synthesis of bioactive cyclobutane natural products |
| title_short | Contemporary synthesis of bioactive cyclobutane natural products |
| title_sort | contemporary synthesis of bioactive cyclobutane natural products |
| topic | Cyclobutane Natural products Bioactive Synthetic methodology Chemical synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S2666554922000370 |
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