Role of gestational age and maternal biological factors in early term neonatal morbidity
Background: The morbidity of early-term newborns (ETNBs) is associated with the immaturity of their organs and maternal biological factors (MBF). In this study, we determined the relationship between MBF and early-term birth. In addition, we assessed the role of gestational age (GA) and MBF in the m...
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Permanyer
2023-07-01
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| Series: | Boletín Médico del Hospital Infantil de México |
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| Online Access: | https://www.bmhim.com/frame_esp.php?id=370 |
| _version_ | 1797777022190092288 |
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| author | Claudia Alarcón-Avila Juanita Monsalve-Montezuma David Guarin-Molano Natalia Pirabán-Gálvez Laura Alonso-Rico Daniela Osorio-Beltran Eliana Rodríguez-Grande |
| author_facet | Claudia Alarcón-Avila Juanita Monsalve-Montezuma David Guarin-Molano Natalia Pirabán-Gálvez Laura Alonso-Rico Daniela Osorio-Beltran Eliana Rodríguez-Grande |
| author_sort | Claudia Alarcón-Avila |
| collection | DOAJ |
| description | Background: The morbidity of early-term newborns (ETNBs) is associated with the immaturity of their organs and maternal biological factors (MBF). In this study, we determined the relationship between MBF and early-term birth. In addition, we assessed the role of gestational age (GA) and MBF in the morbidity of ETNBs compared with full-term newborns (FTNBs). Methods: This retrospective cohort included ETNBs and FTNBs. The frequency of morbidities was compared between groups stratified by GA with the X2 test or Fisher’s exact test. The association of MBF with GA and morbidity was calculated using binomial regression models between the variables that correlated with the morbidity of the ETNBs using Spearman’s correlation. A significance level of 5% was estimated for all analyses. Results: The probability of morbidity at birth for ETNBs was 1.9-fold higher than for FTNBs (37.5% vs. 19.9%), as they required more admission to the neonatal unit and more days of hospitalization; the most frequent pathology was jaundice. The MBF associated with early term birth were hypertensive disorders of pregnancy (aRR = 1.4, 95% confidence interval (CI): 1.3–1.6), intrauterine growth restriction (aRR = 1.5, 95%CI: 1.3–1.6), and chronic hypertension (aRR = 1.6, 95%CI: 1.4–1.8). No association was found between MBF and morbidity at 37 and 38 weeks. Conclusions: The morbidity among ETNBs is related to physiological immaturity. The adverse MBF favor a hostile intrauterine environment, which affects fetal and neonatal well-being.
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| first_indexed | 2024-03-12T22:58:10Z |
| format | Article |
| id | doaj.art-bec5258fac3a4e9a8b6e9ba358f28735 |
| institution | Directory Open Access Journal |
| issn | 0539-6115 |
| language | English |
| last_indexed | 2024-03-12T22:58:10Z |
| publishDate | 2023-07-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Boletín Médico del Hospital Infantil de México |
| spelling | doaj.art-bec5258fac3a4e9a8b6e9ba358f287352023-07-19T19:33:31ZengPermanyerBoletín Médico del Hospital Infantil de México0539-61152023-07-0180310.24875/BMHIM.22000120Role of gestational age and maternal biological factors in early term neonatal morbidityClaudia Alarcón-Avila0Juanita Monsalve-Montezuma1David Guarin-Molano2Natalia Pirabán-GálvezLaura Alonso-Rico3Daniela Osorio-Beltran4Eliana Rodríguez-Grande5Universidad Militar Nueva Granada; Hospital Militar Central; Bogotá, ColombiaUniversidad Militar Nueva Granada, Bogotá, ColombiaUniversidad Militar Nueva Granada, Bogotá, ColombiaUniversidad Militar Nueva Granada, Bogootá, ColombiaUniversidad Militar Nueva Granada, Bogotá, ColombiaHospital Militar Central; Universidad del Rosario. Bogotá, ColombiaBackground: The morbidity of early-term newborns (ETNBs) is associated with the immaturity of their organs and maternal biological factors (MBF). In this study, we determined the relationship between MBF and early-term birth. In addition, we assessed the role of gestational age (GA) and MBF in the morbidity of ETNBs compared with full-term newborns (FTNBs). Methods: This retrospective cohort included ETNBs and FTNBs. The frequency of morbidities was compared between groups stratified by GA with the X2 test or Fisher’s exact test. The association of MBF with GA and morbidity was calculated using binomial regression models between the variables that correlated with the morbidity of the ETNBs using Spearman’s correlation. A significance level of 5% was estimated for all analyses. Results: The probability of morbidity at birth for ETNBs was 1.9-fold higher than for FTNBs (37.5% vs. 19.9%), as they required more admission to the neonatal unit and more days of hospitalization; the most frequent pathology was jaundice. The MBF associated with early term birth were hypertensive disorders of pregnancy (aRR = 1.4, 95% confidence interval (CI): 1.3–1.6), intrauterine growth restriction (aRR = 1.5, 95%CI: 1.3–1.6), and chronic hypertension (aRR = 1.6, 95%CI: 1.4–1.8). No association was found between MBF and morbidity at 37 and 38 weeks. Conclusions: The morbidity among ETNBs is related to physiological immaturity. The adverse MBF favor a hostile intrauterine environment, which affects fetal and neonatal well-being. https://www.bmhim.com/frame_esp.php?id=370Newborn. Morbidity. Biological factors. Gestational age. |
| spellingShingle | Claudia Alarcón-Avila Juanita Monsalve-Montezuma David Guarin-Molano Natalia Pirabán-Gálvez Laura Alonso-Rico Daniela Osorio-Beltran Eliana Rodríguez-Grande Role of gestational age and maternal biological factors in early term neonatal morbidity Boletín Médico del Hospital Infantil de México Newborn. Morbidity. Biological factors. Gestational age. |
| title | Role of gestational age and maternal biological factors in early term neonatal morbidity |
| title_full | Role of gestational age and maternal biological factors in early term neonatal morbidity |
| title_fullStr | Role of gestational age and maternal biological factors in early term neonatal morbidity |
| title_full_unstemmed | Role of gestational age and maternal biological factors in early term neonatal morbidity |
| title_short | Role of gestational age and maternal biological factors in early term neonatal morbidity |
| title_sort | role of gestational age and maternal biological factors in early term neonatal morbidity |
| topic | Newborn. Morbidity. Biological factors. Gestational age. |
| url | https://www.bmhim.com/frame_esp.php?id=370 |
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