| Summary: | Prema K Chande,1 Rajiv Raman,2 Preethi John,3 Sangeetha Srinivasan4 1Chitkara School of Health Sciences and Lotus College of Optometry, Mumbai, India; 2Sankara Nethralaya, Medical Research Foundation, Chennai, India; 3Chitkara School of Health Sciences, Chitkara University, Rajpura, Punjab, India; 4Vision Research Foundation, Chennai, IndiaCorrespondence: Prema K ChandeLotus College of Optometry, 13th North South Road, Vithal Nagar, Juhu, Mumbai, Maharashtra 400049, India, Tel +91-98-2016-4222Email prema@lcoo.edu.inPurpose: The purpose of this study was to assess contrast sensitivity and macular function test in prediabetes.Methods: Participants aged 25– 45 years with or without diabetes were enrolled and classified as normal, prediabetic, and diabetic based on their HbA1C values. They underwent a comprehensive eye examination, and those with diabetic retinopathy, cataract, glaucoma, and high myopia were excluded. Participants with best-corrected visual acuity of 0 logMAR were included. Contrast-sensitivity function (CSF) was measured using a Pelli–Robson chart, and photo stress–recovery time (PSRT) assessed using direct ophthalmoscopy for the 70 eligible participants. Mean values were compared among the three groups.Design: This was a cross-sectional observational study.Results: In the 70 participants, mean CSF was 1.71± 0.10, 1.64± 0.11, and 1.61± 0.08 log units in the normal, prediabetic, and diabetic groups, respectively (p< 0.001). Similarly, PSRT was found to be 35.80 seconds, 41.63 seconds, and 47.77 seconds in the normal, prediabetic, and diabetic groups, respectively (p< 0.001).Conclusion: The data suggested that reduced CSF and delayed PSRT seen in subjects with prediabetes could give valuable clinical insight into early changes before diabetes and microvascular damage is incurred. A future study with a larger sample could help substantiate the results.Keywords: contrast-sensitivity function, prediabetes, diabetes, HbA1C, photo stress–recovery test
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