Tomatidine Represses Invasion and Migration of Human Osteosarcoma U2OS and HOS Cells by Suppression of Presenilin 1 and c-Raf–MEK–ERK Pathway

Tomatidine Represses Invasion and Migration of Human Osteosarcoma U2OS and HOS Cells by Suppression of Presenilin 1 and c-Raf–MEK–ERK Pathway

Osteosarcoma, which is the most prevalent malignant bone tumor, is responsible for the great majority of bone cancer-associated deaths because of its highly metastatic potential. Although tomatidine is suggested to serve as a chemosensitizer in multidrug-resistant tumors, the anti-metastatic effect...

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Bibliographic Details
Main Authors: Min-Hong Hsieh, Jia-Sin Yang, Renn-Chia Lin, Yi-Hsien Hsieh, Shun-Fa Yang, Horng-Rong Chang, Ko-Hsiu Lu
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
erk
metastasis
osteosarcoma
ps-1
tomatidine
Online Access:https://www.mdpi.com/1420-3049/25/2/326

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