Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans
IntroductionThis study sought to determine the effect of Occupational Safety and Health Administration (OSHA) compliant noise on auditory health and assess whether pre-noise near infrared (NIR) light therapy can mitigate the effects of noise exposure.MethodsOver four visits, participants (n = 30, NC...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1366239/full |
| _version_ | 1827276464475602944 |
|---|---|
| author | Erin Williams Erin Williams Erin Williams Kayla Minesinger Kayla Minesinger Hilary Gallagher J. R. Stefanson Nathaniel Bridges Natalie Jackson Valerie Stark Jennifer Coto Suhrud Rajguru Suhrud Rajguru Kurt Yankaskas Rick Rogers Michael E. Hoffer Michael E. Hoffer |
| author_facet | Erin Williams Erin Williams Erin Williams Kayla Minesinger Kayla Minesinger Hilary Gallagher J. R. Stefanson Nathaniel Bridges Natalie Jackson Valerie Stark Jennifer Coto Suhrud Rajguru Suhrud Rajguru Kurt Yankaskas Rick Rogers Michael E. Hoffer Michael E. Hoffer |
| author_sort | Erin Williams |
| collection | DOAJ |
| description | IntroductionThis study sought to determine the effect of Occupational Safety and Health Administration (OSHA) compliant noise on auditory health and assess whether pre-noise near infrared (NIR) light therapy can mitigate the effects of noise exposure.MethodsOver four visits, participants (n = 30, NCT#: 03834714) with normal hearing completed baseline hearing health assessments followed by exposure to open ear, continuous pink noise at 94 dBA for 15 min. Immediately thereafter, post-noise hearing tests at 3000, 4000, and 6000 Hz and distortion product otoacoustic emissions (DPOAEs) were conducted along with the Modified Rhyme Test (MRT), Masking Level Difference Test (MLD), and Fixed Level Frequency Tests (FLFT) [collectively referred to as the Central and Peripheral Auditory Test Battery (CPATB)] to acquire baseline noise sensitivity profiles. Participants were then randomized to either Active or Sham NIR light therapy for 30 min binaurally to conclude Visit 1. Visit 2 (≥24 and ≤ 48 h from Visit 1) began with an additional 30-min session of Active NIR light therapy or Sham followed by repeat CPATB testing and noise exposure. Post-noise testing was again conducted immediately after noise exposure to assess the effect of NIR light therapy. The remaining visits were conducted following ≥2 weeks of noise rest in a cross-over design (i.e., those who had received Active NIR light therapy in Visits 1 and 2 received Sham therapy in Visits 3 and 4).ResultsRecovery hearing tests and DPOAEs were completed at the end of each visit. Participants experienced temporary threshold shifts (TTS) immediately following noise exposure, with a mean shift of 6.79 dB HL (±6.25), 10.61 dB HL (±6.89), and 7.30 dB HL (±7.25) at 3000, 4000, and 6000 Hz, respectively, though all thresholds returned to baseline at 3000, 4000, and 6000 Hz within 75 min of noise exposure. Paradoxically, Active NIR light therapy threshold shifts were statistically higher than Sham therapy at 3000 Hz (p = 0.04), but no other differences were observed at the other frequencies tested. An age sub-analysis demonstrated that TTS among younger adults were generally larger in the Sham therapy group versus Active therapy, though this was not statistically different. There were no differences in CPATB test results across Active or Sham groups. Finally, we observed no changes in auditory function or central processing following noise exposure, suggestive of healthy and resilient inner ears.ConclusionIn this study, locally administered NIR prior to noise exposure did not induce a significant protective effect in mitigating noise-induced TTS. Further exploration is needed to implement effective dosage and administration for this promising otoprotective therapy. |
| first_indexed | 2024-04-24T06:49:10Z |
| format | Article |
| id | doaj.art-bec93cf5a5ba4bafb6d39d6e2eb96414 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T06:49:10Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-bec93cf5a5ba4bafb6d39d6e2eb964142024-04-22T14:24:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-04-011510.3389/fneur.2024.13662391366239Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humansErin Williams0Erin Williams1Erin Williams2Kayla Minesinger3Kayla Minesinger4Hilary Gallagher5J. R. Stefanson6Nathaniel Bridges7Natalie Jackson8Valerie Stark9Jennifer Coto10Suhrud Rajguru11Suhrud Rajguru12Kurt Yankaskas13Rick Rogers14Michael E. Hoffer15Michael E. Hoffer16Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL, United StatesAir Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, Dayton, OH, United StatesU.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, United StatesAir Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, Dayton, OH, United StatesOak Ridge Institute for Science and Education, Oak Ridge, TN, United StatesUniversity of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL, United StatesBioInnovations Institute, Natick, MA, United StatesBioInnovations Institute, Natick, MA, United StatesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesIntroductionThis study sought to determine the effect of Occupational Safety and Health Administration (OSHA) compliant noise on auditory health and assess whether pre-noise near infrared (NIR) light therapy can mitigate the effects of noise exposure.MethodsOver four visits, participants (n = 30, NCT#: 03834714) with normal hearing completed baseline hearing health assessments followed by exposure to open ear, continuous pink noise at 94 dBA for 15 min. Immediately thereafter, post-noise hearing tests at 3000, 4000, and 6000 Hz and distortion product otoacoustic emissions (DPOAEs) were conducted along with the Modified Rhyme Test (MRT), Masking Level Difference Test (MLD), and Fixed Level Frequency Tests (FLFT) [collectively referred to as the Central and Peripheral Auditory Test Battery (CPATB)] to acquire baseline noise sensitivity profiles. Participants were then randomized to either Active or Sham NIR light therapy for 30 min binaurally to conclude Visit 1. Visit 2 (≥24 and ≤ 48 h from Visit 1) began with an additional 30-min session of Active NIR light therapy or Sham followed by repeat CPATB testing and noise exposure. Post-noise testing was again conducted immediately after noise exposure to assess the effect of NIR light therapy. The remaining visits were conducted following ≥2 weeks of noise rest in a cross-over design (i.e., those who had received Active NIR light therapy in Visits 1 and 2 received Sham therapy in Visits 3 and 4).ResultsRecovery hearing tests and DPOAEs were completed at the end of each visit. Participants experienced temporary threshold shifts (TTS) immediately following noise exposure, with a mean shift of 6.79 dB HL (±6.25), 10.61 dB HL (±6.89), and 7.30 dB HL (±7.25) at 3000, 4000, and 6000 Hz, respectively, though all thresholds returned to baseline at 3000, 4000, and 6000 Hz within 75 min of noise exposure. Paradoxically, Active NIR light therapy threshold shifts were statistically higher than Sham therapy at 3000 Hz (p = 0.04), but no other differences were observed at the other frequencies tested. An age sub-analysis demonstrated that TTS among younger adults were generally larger in the Sham therapy group versus Active therapy, though this was not statistically different. There were no differences in CPATB test results across Active or Sham groups. Finally, we observed no changes in auditory function or central processing following noise exposure, suggestive of healthy and resilient inner ears.ConclusionIn this study, locally administered NIR prior to noise exposure did not induce a significant protective effect in mitigating noise-induced TTS. Further exploration is needed to implement effective dosage and administration for this promising otoprotective therapy.https://www.frontiersin.org/articles/10.3389/fneur.2024.1366239/fullnear-infrared lightnoise-induced hearing losstemporary threshold shiftauditory therapeuticsauditory health |
| spellingShingle | Erin Williams Erin Williams Erin Williams Kayla Minesinger Kayla Minesinger Hilary Gallagher J. R. Stefanson Nathaniel Bridges Natalie Jackson Valerie Stark Jennifer Coto Suhrud Rajguru Suhrud Rajguru Kurt Yankaskas Rick Rogers Michael E. Hoffer Michael E. Hoffer Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans Frontiers in Neurology near-infrared light noise-induced hearing loss temporary threshold shift auditory therapeutics auditory health |
| title | Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans |
| title_full | Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans |
| title_fullStr | Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans |
| title_full_unstemmed | Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans |
| title_short | Examining the utility of near infrared light as pre-exposure therapy to mitigate temporary noise-induced hearing loss in humans |
| title_sort | examining the utility of near infrared light as pre exposure therapy to mitigate temporary noise induced hearing loss in humans |
| topic | near-infrared light noise-induced hearing loss temporary threshold shift auditory therapeutics auditory health |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1366239/full |
| work_keys_str_mv | AT erinwilliams examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT erinwilliams examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT erinwilliams examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT kaylaminesinger examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT kaylaminesinger examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT hilarygallagher examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT jrstefanson examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT nathanielbridges examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT nataliejackson examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT valeriestark examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT jennifercoto examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT suhrudrajguru examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT suhrudrajguru examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT kurtyankaskas examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT rickrogers examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT michaelehoffer examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans AT michaelehoffer examiningtheutilityofnearinfraredlightaspreexposuretherapytomitigatetemporarynoiseinducedhearinglossinhumans |