Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic immunity and autoimmune disorders. We have previously found that oxymatrine (OMT), a natural alkaloid, can alleviate rheumatoid arthritis without knowing whether OMT can alleviate rheumatoid arthritis through gut mic...
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MDPI AG
2023-08-01
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5879 |
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| author | Gan Cao Jing Li Zhuhan Mao Yanli Zhang |
| author_facet | Gan Cao Jing Li Zhuhan Mao Yanli Zhang |
| author_sort | Gan Cao |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic immunity and autoimmune disorders. We have previously found that oxymatrine (OMT), a natural alkaloid, can alleviate rheumatoid arthritis without knowing whether OMT can alleviate rheumatoid arthritis through gut microbiota. In this study, we found that OMT can alleviate collagen-induced arthritis in mice and reconstruct the immune balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells. Colon transcriptome gene enrichment analysis indicated that oxymatrine may alleviate collagen induced arthritis in mice through immune system process pathway. Furthermore, OMT significantly altered the gut microbiota variety, changed the composition of microbial colonies, and reshaped the gut microbiota of collagen-induced arthritis (CIA) mice, which may participate in the regulation of the balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells to alleviate collagen-induced arthritis in mice. |
| first_indexed | 2024-03-11T00:20:49Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:49Z |
| publishDate | 2023-08-01 |
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| series | Molecules |
| spelling | doaj.art-beca47dd58c04b1d88278f716f68816e2023-11-18T23:20:10ZengMDPI AGMolecules1420-30492023-08-012815587910.3390/molecules28155879Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T CellsGan Cao0Jing Li1Zhuhan Mao2Yanli Zhang3Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, ChinaRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic immunity and autoimmune disorders. We have previously found that oxymatrine (OMT), a natural alkaloid, can alleviate rheumatoid arthritis without knowing whether OMT can alleviate rheumatoid arthritis through gut microbiota. In this study, we found that OMT can alleviate collagen-induced arthritis in mice and reconstruct the immune balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells. Colon transcriptome gene enrichment analysis indicated that oxymatrine may alleviate collagen induced arthritis in mice through immune system process pathway. Furthermore, OMT significantly altered the gut microbiota variety, changed the composition of microbial colonies, and reshaped the gut microbiota of collagen-induced arthritis (CIA) mice, which may participate in the regulation of the balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells to alleviate collagen-induced arthritis in mice.https://www.mdpi.com/1420-3049/28/15/5879gut microbiotaTh celloxymatrine |
| spellingShingle | Gan Cao Jing Li Zhuhan Mao Yanli Zhang Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells Molecules gut microbiota Th cell oxymatrine |
| title | Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells |
| title_full | Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells |
| title_fullStr | Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells |
| title_full_unstemmed | Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells |
| title_short | Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells |
| title_sort | oxymatrine alleviates collagen induced arthritis in mice by regulating the immune balance of t cells |
| topic | gut microbiota Th cell oxymatrine |
| url | https://www.mdpi.com/1420-3049/28/15/5879 |
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