Systemic tryptophan homeostasis

Systemic tryptophan homeostasis

Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H), kynurenic acid, melatonin and serotonin. It also plays a role in immune homeostasis, as local tryptophan...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Simon Klaessens, Vincent Stroobant, Etienne De Plaen, Benoit J. Van den Eynde
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Frontiers Media S.A. 2022-09-01
Cyfres:	Frontiers in Molecular Biosciences
Pynciau:	tryptophan TDO (tryptophan 2,3-dioxygenase) IDO1 (indoleamine 2,3-dioxygenase 1) pellagra hartnup disease tumor
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.897929/full

Eitemau Tebyg

Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance
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Cyhoeddwyd: (2020-12-01)

Tryptophan-degrading enzymes in tumoral immune resistance
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On the nonredundant roles of TDO2 and IDO1
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Editorial: Heme proteins: key players in the regulation of immune responses
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Cyhoeddwyd: (2023-08-01)

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
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Cyhoeddwyd: (2017-10-01)

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target
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Cyhoeddwyd: (2019-10-01)

The Two Sides of Indoleamine 2,3-Dioxygenase 2 (IDO2)
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Cyhoeddwyd: (2024-11-01)

Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
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Cyhoeddwyd: (2017-03-01)

What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past
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Cyhoeddwyd: (2021-02-01)

TRYPTOPHAN AND INDOLEAMINE-2,3-DIOXYGENASE (IDO) IN PATHOGENESIS OF IMMUNOSUPPRESSIVE CLINICAL CONDITIONS
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Cyhoeddwyd: (2017-07-01)

Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma
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Cyhoeddwyd: (2017-08-01)

Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway
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Cyhoeddwyd: (2024-11-01)

IDO Expression in Cancer: Different Compartment, Different Functionality?
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Cyhoeddwyd: (2020-09-01)

Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders
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Cyhoeddwyd: (2024-07-01)

Pharmacological Targets of Kaempferol Within Inflammatory Pathways—A Hint Towards the Central Role of Tryptophan Metabolism
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Cyhoeddwyd: (2020-02-01)

The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1
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Cyhoeddwyd: (2023-04-01)

Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives
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Cyhoeddwyd: (2022-01-01)

The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism
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Cyhoeddwyd: (2010-08-01)

Serial Analysis of Tryptophan Degradation and Neopterin Formation in an otherwise Healthy Individual before and during an Infectious Episode
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Cyhoeddwyd: (2006-02-01)

Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells
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Cyhoeddwyd: (2021-03-01)

Exploring a repurposed candidate with dual hIDO1/hTDO2 inhibitory potential for anticancer efficacy identified through pharmacophore-based virtual screening and in vitro evaluation
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Cyhoeddwyd: (2024-04-01)

Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy
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Cyhoeddwyd: (2019-07-01)

AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases
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Cyhoeddwyd: (2021-07-01)

Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
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Cyhoeddwyd: (2004-04-01)

The Kynurenine Pathway As a Novel Link between Allergy and the Gut Microbiome
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Cyhoeddwyd: (2017-11-01)

Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors
gan: Chuan Zhou, et al.
Cyhoeddwyd: (2020-03-01)

The role of tryptophan in Chlamydia trachomatis persistence
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Cyhoeddwyd: (2022-08-01)

Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in weaned pigs
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Cyhoeddwyd: (2012-01-01)

Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1
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Cyhoeddwyd: (2020-07-01)

Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers
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Cyhoeddwyd: (2018-10-01)

In vitro Effects of Nigella sativa Seeds Extracts on Stimulated Peripheral Blood Mononuclear Cells
gan: Winkler Christiana, et al.
Cyhoeddwyd: (2008-02-01)

Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges
gan: Peng X, et al.
Cyhoeddwyd: (2022-08-01)

Tryptophan Breakdown in Patients with HCV Infection is Influenced by IL28B Polymorphism
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Cyhoeddwyd: (2015-06-01)

PEG-Poly(1-Methyl-<span style="font-variant: small-caps">l</span>-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase
gan: George Lo Huang, et al.
Cyhoeddwyd: (2019-05-01)

Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer
gan: A. Marijne Heeren, et al.
Cyhoeddwyd: (2018-07-01)

The Coevolution of IDO1 and AhR in the Emergence of Regulatory T Cells in Mammals
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Cyhoeddwyd: (2015-02-01)

Exposure to Helicobacter pylori and Serum Kynurenine to Tryptophan Ratio in Patients with Gastric Cancer
gan: Engin Ayse Basak, et al.
Cyhoeddwyd: (2010-02-01)

Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer’s Disease and Geriatric Depression
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Cyhoeddwyd: (2023-05-01)

An exploratory study of neopterin and kynurenine pathway in pterygium
gan: Kilicarslan Bilge, et al.
Cyhoeddwyd: (2019-08-01)

Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis
gan: Tingbin Xie, et al.
Cyhoeddwyd: (2023-04-01)