Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types
Porcine circovirus type 4 (PCV4) is a newly identified porcine circovirus (PCV) belonging to the <i>Circovirus</i> genus <i>Circoviridae</i> family. Although several groups have conducted epidemiological investigations on PCV4 and found that PCV4 also exists widely in pigs, t...
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/6/3288 |
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| author | Xue Li Si Chen Guyu Niu Xinwei Zhang Weilong Ji Ying Ren Liying Zhang Linzhu Ren |
| author_facet | Xue Li Si Chen Guyu Niu Xinwei Zhang Weilong Ji Ying Ren Liying Zhang Linzhu Ren |
| author_sort | Xue Li |
| collection | DOAJ |
| description | Porcine circovirus type 4 (PCV4) is a newly identified porcine circovirus (PCV) belonging to the <i>Circovirus</i> genus <i>Circoviridae</i> family. Although several groups have conducted epidemiological investigations on PCV4 and found that PCV4 also exists widely in pigs, there are few reports on the origin and evolution of PCV4. In this study, the genetic relationship between PCV4, mink circovirus (MiCV), bat circovirus (BtCV), PCV1, PCV2, and PCV3 was analyzed, and the consistency of viral proteins in three-dimensional (3D) structure and epitopes was predicted. We found that the genome and protein structure of PCV4 was relatively stable among current circulating PCV4 strains. Furthermore, PCV4 was more similar to MiCV in terms of its genome, protein structure, and epitope levels than other PCVs and BtCVs, suggesting that PCV4 may be derived from MiCV or have a common origin with MiCV, or mink may be an intermediate host of PCV4, which may pose a great threat to other animals and/or even human beings. Therefore, it is necessary to continuously monitor the infection and variation of PCV4, analyze the host spectrum of PCV4, and establish the prevention and treatment methods of PCV4 infection in advance. |
| first_indexed | 2024-03-09T19:41:43Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:41:43Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-beccf7719ba24b7b8b21bd65ca7457c92023-11-24T01:36:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236328810.3390/ijms23063288Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus TypesXue Li0Si Chen1Guyu Niu2Xinwei Zhang3Weilong Ji4Ying Ren5Liying Zhang6Linzhu Ren7College of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaPublic Computer Education and Research Center, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, 5333 Xi’an Road, Changchun 130062, ChinaPorcine circovirus type 4 (PCV4) is a newly identified porcine circovirus (PCV) belonging to the <i>Circovirus</i> genus <i>Circoviridae</i> family. Although several groups have conducted epidemiological investigations on PCV4 and found that PCV4 also exists widely in pigs, there are few reports on the origin and evolution of PCV4. In this study, the genetic relationship between PCV4, mink circovirus (MiCV), bat circovirus (BtCV), PCV1, PCV2, and PCV3 was analyzed, and the consistency of viral proteins in three-dimensional (3D) structure and epitopes was predicted. We found that the genome and protein structure of PCV4 was relatively stable among current circulating PCV4 strains. Furthermore, PCV4 was more similar to MiCV in terms of its genome, protein structure, and epitope levels than other PCVs and BtCVs, suggesting that PCV4 may be derived from MiCV or have a common origin with MiCV, or mink may be an intermediate host of PCV4, which may pose a great threat to other animals and/or even human beings. Therefore, it is necessary to continuously monitor the infection and variation of PCV4, analyze the host spectrum of PCV4, and establish the prevention and treatment methods of PCV4 infection in advance.https://www.mdpi.com/1422-0067/23/6/3288porcine circovirus type 4 (PCV4)three-dimensional (3D) structures modelingepitopehomologymink circovirus (MiCV)evolution |
| spellingShingle | Xue Li Si Chen Guyu Niu Xinwei Zhang Weilong Ji Ying Ren Liying Zhang Linzhu Ren Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types International Journal of Molecular Sciences porcine circovirus type 4 (PCV4) three-dimensional (3D) structures modeling epitope homology mink circovirus (MiCV) evolution |
| title | Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types |
| title_full | Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types |
| title_fullStr | Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types |
| title_full_unstemmed | Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types |
| title_short | Porcine Circovirus Type 4 Strains Circulating in China Are Relatively Stable and Have Higher Homology with Mink Circovirus than Other Porcine Circovirus Types |
| title_sort | porcine circovirus type 4 strains circulating in china are relatively stable and have higher homology with mink circovirus than other porcine circovirus types |
| topic | porcine circovirus type 4 (PCV4) three-dimensional (3D) structures modeling epitope homology mink circovirus (MiCV) evolution |
| url | https://www.mdpi.com/1422-0067/23/6/3288 |
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