Colon Transcriptomics Reveals Sex-Dependent Metabolic Signatures in Response to 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Treatment in C57BL/6N Mice

Colon Transcriptomics Reveals Sex-Dependent Metabolic Signatures in Response to 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Treatment in C57BL/6N Mice

Diets high in red meats, particularly meats cooked at high temperature, increase the risk of colon cancer due to a production of heterocyclic aromatic amines (HAAs). Of the identified HAAs, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most mass abundant colon carcinogen in charred m...

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Bibliographic Details
Main Authors: Jeong Hoon Pan, Cara Cicalo, Brandy Le, Suwon Jeon, Sangyub Kim, Kyung A. Hwang, Byungwhi Kong, Jin Hyup Lee, Jae Kyeom Kim
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
colonic transcriptome
sex-based difference
lipolysis
mitochondrial dysfunction
PhIP metabolism
Online Access:https://www.mdpi.com/1422-0067/21/18/6620

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