The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
Abstract Background Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. Case presentation We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ib...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-10-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40463-019-0376-1 |
| _version_ | 1826910309065949184 |
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| author | Marco A. Mascarella Lorne Schweitzer Mahmoud Alreefi Jennifer Silver Derin Caglar Vivian G. Loo Keith Richardson Philippe Dufresne Todd C. Lee Nader Sadeghi |
| author_facet | Marco A. Mascarella Lorne Schweitzer Mahmoud Alreefi Jennifer Silver Derin Caglar Vivian G. Loo Keith Richardson Philippe Dufresne Todd C. Lee Nader Sadeghi |
| author_sort | Marco A. Mascarella |
| collection | DOAJ |
| description | Abstract Background Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. Case presentation We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. Conclusion Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck. |
| first_indexed | 2024-04-11T03:51:14Z |
| format | Article |
| id | doaj.art-becdd75854574f2da6a66e32dd3bef9a |
| institution | Directory Open Access Journal |
| issn | 1916-0216 |
| language | English |
| last_indexed | 2025-02-17T09:57:21Z |
| publishDate | 2019-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj.art-becdd75854574f2da6a66e32dd3bef9a2025-01-02T04:59:15ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162019-10-014811410.1186/s40463-019-0376-1The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapyMarco A. Mascarella0Lorne Schweitzer1Mahmoud Alreefi2Jennifer Silver3Derin Caglar4Vivian G. Loo5Keith Richardson6Philippe Dufresne7Todd C. Lee8Nader Sadeghi9Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health CentreDivision of Infectious Diseases, Department of Medicine, McGill University Health CentreDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health CentreDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health CentreDepartment of Pathology, McGill University Health CentreDivision of Infectious Diseases, Department of Medicine, McGill University Health CentreDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health CentreLaboratoire de Santé Publique du QuébecDivision of Infectious Diseases, Department of Medicine, McGill University Health CentreDepartment of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health CentreAbstract Background Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. Case presentation We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. Conclusion Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.http://link.springer.com/article/10.1186/s40463-019-0376-1MucormycosisThyroid noduleIbrutinibAcute invasive fungal infection |
| spellingShingle | Marco A. Mascarella Lorne Schweitzer Mahmoud Alreefi Jennifer Silver Derin Caglar Vivian G. Loo Keith Richardson Philippe Dufresne Todd C. Lee Nader Sadeghi The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy Journal of Otolaryngology - Head and Neck Surgery Mucormycosis Thyroid nodule Ibrutinib Acute invasive fungal infection |
| title | The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy |
| title_full | The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy |
| title_fullStr | The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy |
| title_full_unstemmed | The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy |
| title_short | The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy |
| title_sort | infectious thyroid nodule a case report of mucormycosis associated with ibrutinib therapy |
| topic | Mucormycosis Thyroid nodule Ibrutinib Acute invasive fungal infection |
| url | http://link.springer.com/article/10.1186/s40463-019-0376-1 |
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